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dc.contributor.author | Basar, A. O. | es_ES |
dc.contributor.author | Castro, S. | es_ES |
dc.contributor.author | Torres-Giner, S. | es_ES |
dc.contributor.author | Lagaron, J. M. | es_ES |
dc.contributor.author | Turkoglu Sasmazel, H. | es_ES |
dc.date.accessioned | 2024-02-05T19:02:25Z | |
dc.date.available | 2024-02-05T19:02:25Z | |
dc.date.issued | 2017-12-01 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/202338 | |
dc.description.abstract | [EN] In the present study, a single and binary Ketoprofen-loaded mats of ultrathin fibers were developed by electrospinning and their physical properties and drug release capacity was analyzed. The single mat was prepared by solution electrospinning of poly(¿-caprolactone) (PCL) with Ketoprofen at a weight ratio of 5wt%. This Ketoprofen-containing PCL solution was also used as the oil phase in a 7:3 (wt/wt) emulsion with gelatin dissolved in acidified water. The resultant stable oil-in-water (O/W) emulsion of PCL-in-gelatin, also containing Ketoprofen at 5wt%, was electrospun to produce the binary mat. Cross-linking process was performed by means of glutaraldehyde vapor on the electrospun binary mat to prevent dissolution of the hydrophilic gelatin phase. The performed characterization indicated that Ketoprofen was successfully embedded in the single and binary electrospun mats, i.e. PCL and PCL/gelatin, and both mats showed high hydrophobicity but poor thermal resistance. In vitro release studies interestingly revealed that, in comparison to the single PCL electrospun mat, the binary PCL/gelatin mat significantly hindered Ketoprofen burst release and exhibited a sustained release capacity of the drug for up to 4days. In addition, the electrospun Ketoprofen-loaded mats showed enhanced attachment and proliferation of L929 mouse fibroblast cells, presenting the binary mat the highest cell growth yield due to its improved porosity. The here-developed electrospun materials clearly show a great deal of potential as novel wound dressings with an outstanding controlled capacity to release drugs. | es_ES |
dc.description.sponsorship | The authors would like to acknowledge the Spanish Ministry of Economy and Competitiveness (MINECO) project AGL2015-63855-C2-1-R for financial support. The authors would also like to thank the European Cooperation Science & Technology (COST) Action MP1206 for their Short Term Scientific Mission (STSM) at IATA-CSIC, Valencia, and the Academic Writing Advisory Center (AWAC) of Atilim University for English language revision. | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | Elsevier BV | es_ES |
dc.relation.ispartof | Materials Science and Engineering C: Biomimetic materials, sensors and systems (Online) | es_ES |
dc.rights | Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) | es_ES |
dc.subject | Drug delivery | es_ES |
dc.subject | Emulsion electrospinning | es_ES |
dc.subject | Gelatin | es_ES |
dc.subject | Ketoprofen | es_ES |
dc.subject | PCL | es_ES |
dc.subject | Wound dressings | es_ES |
dc.title | Novel poly(e-caprolactone)/gelatin wound dressings prepared by emulsion electrospinning with controlled release capacity of Ketoprofen anti-inflammatory drug | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1016/j.msec.2017.08.025 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//AGL2015-63855-C2-1-R/ES/DESARROLLO DE UN CONCEPTO DE ENVASE MULTICAPA ALIMENTARIO DE ALTA BARRERA Y CON CARACTER ACTIVO Y BIOACTIVO DERIVADO DE SUBPRODUCTOS ALIMENTARIOS/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/COST//MP1206/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto Universitario de Ingeniería de Alimentos para el Desarrollo - Institut Universitari d'Enginyeria d'Aliments per al Desenvolupament | es_ES |
dc.description.bibliographicCitation | Basar, AO.; Castro, S.; Torres-Giner, S.; Lagaron, JM.; Turkoglu Sasmazel, H. (2017). Novel poly(e-caprolactone)/gelatin wound dressings prepared by emulsion electrospinning with controlled release capacity of Ketoprofen anti-inflammatory drug. Materials Science and Engineering C: Biomimetic materials, sensors and systems (Online). 81:459-468. https://doi.org/10.1016/j.msec.2017.08.025 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.msec.2017.08.025 | es_ES |
dc.description.upvformatpinicio | 459 | es_ES |
dc.description.upvformatpfin | 468 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 81 | es_ES |
dc.identifier.eissn | 1873-0191 | es_ES |
dc.identifier.pmid | 28887998 | es_ES |
dc.relation.pasarela | S\360864 | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad | es_ES |
dc.contributor.funder | European Cooperation in Science and Technology | es_ES |