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dc.contributor.author | Melero, Ana![]() |
es_ES |
dc.contributor.author | Garrigues, T.M.![]() |
es_ES |
dc.contributor.author | Almudéver-Folch, Patricia![]() |
es_ES |
dc.contributor.author | Martín Villodre, A.![]() |
es_ES |
dc.contributor.author | Lehr, C.M.![]() |
es_ES |
dc.contributor.author | Schäfer, U.![]() |
es_ES |
dc.date.accessioned | 2024-02-07T19:02:13Z | |
dc.date.available | 2024-02-07T19:02:13Z | |
dc.date.issued | 2008-06 | es_ES |
dc.identifier.issn | 0939-6411 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/202397 | |
dc.description.abstract | [EN] The influence of propylen glycol (PG), ethanol, and oleic acid (OA) on nortriptyline hydrochloride (NTH) penetration through human epidermis was studied in vitro at two different pH values (5.5 and 7.4). The influence of lactic acid and polysorbate 80 was studied for a pH of 5.5. Permeation studies through Heat Separated Epidermis, as well as the enhancing effect of the different vehicles, showed a pH dependency. A pH value of 5.5 in the donor solution decreases significantly the permeability coefficient (Kp) with respect to a pH value of 7.4 (0.011+/-0.004 x 10(-6) versus 0.36+/-0.04 x 10(-6)cm/s). The vehicles showed an increasing enhancement effect in the order: polysorbate 80>ethanol/PG/OA>PG>ethanol>ethanol/lactic acid>lactic acid at pH 5.5 while they reduced the permeation of NTH at pH 7.4. Considering the results obtained at pH 5.5, the maximum enhancement ratios were found for polysorbate 80 and the combination ethanol/PG/OA (10.72 and 3.90). Both vehicles were selected for designing a NTH transdermal delivery system (NTH-TDS) using (hydroxypropyl)methyl-cellulose as polymer. The NTH-TDS based on the combination of ethanol/PG/OA showed an enhancement ratio with respect to control of 2.09 and the addition of polysorbate 80 to the matrix, of 5.82. | es_ES |
dc.description.sponsorship | The Galenos Network-Marie Curie-Fellowship agreement in the framework of the EU Project "Towards a European Ph.D. in Advanced Drug Delivery" MESTCT-2004-504992. Funds were received from the Generalitat Valenciana (GV06-163). The authors thank Dr. Javier Pascual (Hospital 9 Octubre, Valencia) and Dr. Karl-Heinz Kostka (Caritas Krankenhaus, Lebach) for providing the human skin samples. | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.ispartof | European Journal of Pharmaceutics and Biopharmaceutics | es_ES |
dc.rights | Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) | es_ES |
dc.subject | Percutaneous absorption | es_ES |
dc.subject | Chemical enhancers | es_ES |
dc.subject | Nortriptyline | es_ES |
dc.subject | TDS | es_ES |
dc.subject | Skin | es_ES |
dc.subject.classification | MICROBIOLOGIA | es_ES |
dc.title | Nortriptyline hydrochloride skin absorption: development of a transdermal patch | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1016/j.ejpb.2007.11.012 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC//MEST-CT-2004-504992//Towards a European Ph.D. in Advanced Drug Delivery (GALENOS Euro-PhD)/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//GV%2F06%2F163/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural | es_ES |
dc.description.bibliographicCitation | Melero, A.; Garrigues, T.; Almudéver-Folch, P.; Martín Villodre, A.; Lehr, C.; Schäfer, U. (2008). Nortriptyline hydrochloride skin absorption: development of a transdermal patch. European Journal of Pharmaceutics and Biopharmaceutics. 69(2):588-596. https://doi.org/10.1016/j.ejpb.2007.11.012 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https:/doi.org/10.1016/j.ejpb.2007.11.012 | es_ES |
dc.description.upvformatpinicio | 588 | es_ES |
dc.description.upvformatpfin | 596 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 69 | es_ES |
dc.description.issue | 2 | es_ES |
dc.identifier.pmid | 18191555 | es_ES |
dc.relation.pasarela | S\427855 | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.subject.ods | 03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades | es_ES |