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dc.contributor.author | Herreros-Pomares, Alejandro | es_ES |
dc.contributor.author | Doria, Paula | es_ES |
dc.contributor.author | Gallach, Sandra | es_ES |
dc.contributor.author | Meri-Abad, Marina | es_ES |
dc.contributor.author | Guijarro, Ricardo | es_ES |
dc.contributor.author | Calabuig-Fariñas, Silvia | es_ES |
dc.contributor.author | Camps, Carlos | es_ES |
dc.contributor.author | Jantus-Lewintre, Eloisa | es_ES |
dc.date.accessioned | 2024-02-29T19:03:06Z | |
dc.date.available | 2024-02-29T19:03:06Z | |
dc.date.issued | 2022-09-21 | es_ES |
dc.identifier.issn | 1068-9265 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/202855 | |
dc.description.abstract | [EN] Background Mutations and deregulations in components of the Hedgehog (Hh) pathway have been associated with cancer onset and tumor growth in different malignancies, but their role in non-small cell lung cancer (NSCLC) remains unclear. This study aims to investigate the expression pattern of the main components of the Hh pathway in tumor and adjacent normal tissue biopsies of resected NSCLC patients. Methods The relative expression of GLI1, PTCH1, SHH, and SMO was analyzed by quantitative polymerase chain reaction (PCR) in a cohort of 245 NSCLC patients. Results were validated in an independent cohort of NSCLC patients from The Cancer Genome Atlas (TCGA). Results We found that SMO and GLI1 were overexpressed in the tumor compared with normal-paired tissue, whereas PTCH1 and SHH were underexpressed. In addition, patients with higher expression levels of PTCH1 presented better outcomes. A gene expression score, called the Hedgehog Score, was calculated using a multivariable model including analyzed components of the Hh signaling pathway. NSCLC patients with a high Hedgehog Score had significantly shorter relapse-free survival (RFS) and overall survival (OS) than patients with a low score, especially at stage I of the disease. Similarly, patients in the adenocarcinoma (ADC) subcohort had shorter RFS and OS. Multivariate Cox analysis exhibited that the Hedgehog Score is an independent prognostic biomarker for OS in both the entire training cohort and the ADC subcohort. The Hedgehog Score was validated in an independent cohort of NSCLC patients from TCGA, which confirmed its prognostic value. Conclusions Our results provide relevant prognostic data for NSCLC patients and support further studies on the Hh pathway. | es_ES |
dc.description.sponsorship | This work was supported by grant no. CB16/12/00350 from the Centro de Investigacion Biomedica en Red de Cancer (CIBEROnc) and Grant No. PI18/00266 from the Instituto de Salud Carlos III (ISCIII). | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | Springer | es_ES |
dc.relation.ispartof | Annals of Surgical Oncology | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Lung cancer | es_ES |
dc.subject | Hedgehog pathway | es_ES |
dc.subject | Cancer Stem Cells | es_ES |
dc.subject | CSC targeting | es_ES |
dc.subject | 60 Tumor treatment | es_ES |
dc.subject | SMO antagonist | es_ES |
dc.subject.classification | BIOLOGIA CELULAR | es_ES |
dc.title | A Sonic Hedgehog Pathway Score to Predict the Outcome of Resected Non-Small Cell Lung Cancer Patients | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1245/s10434-022-12565-2 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI18%2F00266/ES/INMUNOGRAMA NO INVASIVO. APROXIMACION MULTIDIMENSIONAL PARA CARACTERIZAR Y MONITORIZAR EL ESTATUS INMUNE EN CANCER DE PULMON./ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//CB16%2F12%2F00350/ES/CANCER/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI15%2F00753/ES/Caracterización de la Interacción entre Célula Madre Tumoral y Microambiente Inmune en el Cáncer de Pulmón no Microcítico. Implicaciones Traslacionales/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural | es_ES |
dc.description.bibliographicCitation | Herreros-Pomares, A.; Doria, P.; Gallach, S.; Meri-Abad, M.; Guijarro, R.; Calabuig-Fariñas, S.; Camps, C.... (2022). A Sonic Hedgehog Pathway Score to Predict the Outcome of Resected Non-Small Cell Lung Cancer Patients. Annals of Surgical Oncology. 30(2):1225-1235. https://doi.org/10.1245/s10434-022-12565-2 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1245/s10434-022-12565-2 | es_ES |
dc.description.upvformatpinicio | 1225 | es_ES |
dc.description.upvformatpfin | 1235 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 30 | es_ES |
dc.description.issue | 2 | es_ES |
dc.identifier.pmid | 36131117 | es_ES |
dc.relation.pasarela | S\477384 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad | es_ES |