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Singlet oxygen and radical-mediated mechanisms in the oxidative cellular damage photosensitized by the protease inhibitor simeprevir

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Singlet oxygen and radical-mediated mechanisms in the oxidative cellular damage photosensitized by the protease inhibitor simeprevir

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García-Laínez, G.; El Ouardi, M.; Moreno, A.; Lence, E.; González-Bello, C.; Miranda, MÁ.; Andreu, I. (2023). Singlet oxygen and radical-mediated mechanisms in the oxidative cellular damage photosensitized by the protease inhibitor simeprevir. Free Radical Biology and Medicine. 194:42-51. https://doi.org/10.1016/j.freeradbiomed.2022.11.006

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/203295

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Title: Singlet oxygen and radical-mediated mechanisms in the oxidative cellular damage photosensitized by the protease inhibitor simeprevir
Author: García-Laínez, Guillermo El Ouardi, Meryem Moreno, Alejandro Lence, Emilio González-Bello, Concepción Miranda, Miguel Á. Andreu, Inmaculada
UPV Unit: Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials
Issued date:
Abstract:
[EN] Hepatitis C, a liver inflammation caused by the hepatitis C virus (HCV), is treated with antiviral drugs. In this context, simeprevir (SIM) is an NS3/4A protease inhibitor used in HCV genotypes 1 and 4. It is orally ...[+]
Subjects: Antiviral agent , Binding to proteins , Cellular photo(geno)toxicity , Photodamage to biomolecules , Triplet excited state
Copyrigths: Reconocimiento - No comercial (by-nc)
Source:
Free Radical Biology and Medicine. (issn: 0891-5849 )
DOI: 10.1016/j.freeradbiomed.2022.11.006
Publisher:
Elsevier
Publisher version: https://doi.org/10.1016/j.freeradbiomed.2022.11.006
Project ID:
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-105512RB-I00/ES/COMBATIENDO LAS BACTERIAS RESISTENTES A LOS ANTIBIOTICOS Y CONTROLANDO SU EVOLUCION IN VIVO MEDIANTE ESTRATEGIAS INNOVADORAS Y NUEVOS TESTS DE DIAGNOSTICO CLINICO/
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-115010RB-I00/ES/FOTOCOMPORTAMIENTO DE LOS INHIBIDORES DE LA TIROSINA QUINASA: DE DISOLUCION A CELULAS/
info:eu-repo/grantAgreement/Xunta de Galicia//ED431G 2019%2F03/
info:eu-repo/grantAgreement/GAIN//2020-PG067/
Thanks:
Financial support from the Spanish Ministry of Science and Innovation [PID2020-115010RB-I00/AEI/10.13039/501100011033 (I.A), PID2019-105512RB-I00/AEI/10.13039/501100011033 (CG-B) and FPU predoctoral fellowship for M. El ...[+]
Type: Artículo

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