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Identification of a Two-MicroRNA Signature in Plasma as a Novel Biomarker for Very Early Diagnosis of Breast Cancer

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Identification of a Two-MicroRNA Signature in Plasma as a Novel Biomarker for Very Early Diagnosis of Breast Cancer

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dc.contributor.author Adam-Artigues, Anna es_ES
dc.contributor.author Garrido-Cano, Iris es_ES
dc.contributor.author Carbonell-Asins, Juan Antonio es_ES
dc.contributor.author Lameirinhas, Ana es_ES
dc.contributor.author Simón, Soraya es_ES
dc.contributor.author Ortega-Morillo, Belén es_ES
dc.contributor.author Martínez, María Teresa es_ES
dc.contributor.author Hernando, Cristina es_ES
dc.contributor.author Constâncio, Vera es_ES
dc.contributor.author Burgues, Octavio es_ES
dc.contributor.author Bermejo, Begoña es_ES
dc.contributor.author Henrique, Rui es_ES
dc.contributor.author Lluch, Ana es_ES
dc.contributor.author Jerónimo, Carmen es_ES
dc.contributor.author Eroles, Pilar es_ES
dc.contributor.author Cejalvo, Juan Miguel es_ES
dc.date.accessioned 2024-04-29T18:08:39Z
dc.date.available 2024-04-29T18:08:39Z
dc.date.issued 2021-06 es_ES
dc.identifier.uri http://hdl.handle.net/10251/203852
dc.description.abstract [EN] The early diagnosis of breast cancer is essential to improve patients' survival rate. In this context, microRNAs have been described as potential diagnostic biomarkers for breast cancer. Particularly, circulating microRNAs have a strong value as non-invasive biomarkers. Herein, we assessed the potential of a microRNA signature based on miR-30b-5p and miR-99a-5p levels in plasma as a diagnostic biomarker for breast cancer. This two-microRNA signature was constructed by Principal Component Analysis and its prognostic value was assessed in a discovery cohort and blindly validated in a second cohort from an independent institution. ROC curve analysis and biomarker performance parameter evaluation demonstrated that our proposed signature presents a high value as a non-invasive biomarker for very early detection of breast cancer. In addition, pathway enrichment analysis identified three of the well-known pathways involved in cancer as targets of the two microRNAs. es_ES
dc.description.sponsorship This study was financed by grants from the Spanish Ministry of Economy and Competitiveness (MINECO) and FEDER funds (PI18/01219 to P.E. and CB16/12/00481 to A.Ll.) and from the Research Centre of the Portuguese Oncology Institute of Porto (PI 74-CBEG-CI-IPOP-19-2015 to C.J.). A.A.-A. and A.L. were funded by Asociación Española Contra el Cáncer (PRDVA18013LLUC and PRDVA19016LAME). V.C. was funded by Liga Portuguesa Contra o Cancro/Fundação PT. J.M.C. was funded by Sociedad Española de Oncología Médica (Río Hortega-SEOM). The authors are grateful to INCLIVA Biobank (PT17/0015/0049; B.000768 ISCIII) and Valencian Biobanking Network integrated into the Spanish National Biobanks Network and nursing staff from all institutions for collaboration. es_ES
dc.language Inglés es_ES
dc.publisher MDPI AG es_ES
dc.relation.ispartof Cancers es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Breast cancer es_ES
dc.subject MiRNA signature es_ES
dc.subject Biomarker es_ES
dc.subject Early diagnosis es_ES
dc.subject Plasma es_ES
dc.title Identification of a Two-MicroRNA Signature in Plasma as a Novel Biomarker for Very Early Diagnosis of Breast Cancer es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/cancers13112848 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI18%2F01219/ES/CARACTERIZACION Y REPERCUSION TERAPEUTICA DE LA ECOLOGIA DE CANCER DE MAMA HER2 POSITIVO/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//CB16%2F12%2F00481/ES/CANCER/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ISCIII//B.000768/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AECC//PRDVA19016LAME/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AECC//PRDVA18013LLUC/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Instituto de Investigación Sanitaria INCLIVA//PT17%2F0015%2F0049//Control de Calidad de Muestras de la Red Nacional de Biobancos 2020/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/IPO Porto//PI 74-CBEG-CI-IPOP-19-2015/ es_ES
dc.rights.accessRights Abierto es_ES
dc.description.bibliographicCitation Adam-Artigues, A.; Garrido-Cano, I.; Carbonell-Asins, JA.; Lameirinhas, A.; Simón, S.; Ortega-Morillo, B.; Martínez, MT.... (2021). Identification of a Two-MicroRNA Signature in Plasma as a Novel Biomarker for Very Early Diagnosis of Breast Cancer. Cancers. 13(11). https://doi.org/10.3390/cancers13112848 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.3390/cancers13112848 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 13 es_ES
dc.description.issue 11 es_ES
dc.identifier.eissn 2072-6694 es_ES
dc.identifier.pmid 34200463 es_ES
dc.identifier.pmcid PMC8201361 es_ES
dc.relation.pasarela S\439373 es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder Asociación Española Contra el Cáncer es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder Instituto de Investigación Sanitaria INCLIVA es_ES
dc.contributor.funder Instituto Português de Oncologia do Porto Francisco Gentil es_ES


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