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dc.contributor.author | Andrés, Diana | es_ES |
dc.contributor.author | Rivens, Ian | es_ES |
dc.contributor.author | Mouratidis, Petros | es_ES |
dc.contributor.author | Jimenez, Noe | es_ES |
dc.contributor.author | Camarena Femenia, Francisco | es_ES |
dc.contributor.author | Ter Haar, Gail | es_ES |
dc.date.accessioned | 2024-04-30T18:06:41Z | |
dc.date.available | 2024-04-30T18:06:41Z | |
dc.date.issued | 2023-04-28 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/203875 | |
dc.description.abstract | [EN] Hyperthermia is currently used to treat cancer due to its ability to radio- and chemo-sensitize and to stimulate the immune response. While ultrasound is non-ionizing and can induce hyperthermia deep within the body non-invasively, achieving uniform and volumetric hyperthermia is challenging. This work presents a novel focused ultrasound hyperthermia system based on 3D-printed acoustic holograms combined with a high-intensity focused ultrasound (HIFU) transducer to produce a uniform iso-thermal dose in multiple targets. The system is designed with the aim of treating several 3D cell aggregates contained in an International Electrotechnical Commission (IEC) tissue-mimicking phantom with multiple wells, each holding a single tumor spheroid, with real-time temperature and thermal dose monitoring. System performance was validated using acoustic and thermal methods, ultimately yielding thermal doses in three wells that differed by less than 4%. The system was tested in vitro for delivery of thermal doses of 0-120 cumulative equivalent minutes at 43 °C (CEM43) to spheroids of U87-MG glioma cells. The effects of ultrasound-induced heating on the growth of these spheroids were compared with heating using a polymerase chain reaction (PCR) thermocycler. Results showed that exposing U87-MG spheroids to an ultrasound-induced thermal dose of 120 CEM43 shrank them by 15% and decreased their growth and metabolic activity more than seen in those exposed to a thermocycler-induced heating. This low-cost approach of modifying a HIFU transducer to deliver ultrasound hyperthermia opens new avenues for accurately controlling thermal dose delivery to complex therapeutic targets using tailored acoustic holograms. Spheroid data show that thermal and non-thermal mechanisms are implicated in the response of cancer cells to non-ablative ultrasound heating. | es_ES |
dc.description.sponsorship | This research has been supported by the Spanish Ministry of Science, Innovation and Universities (MICIU) through grants "Formacion de Profesorado Universitario" FPU19/00601 and EST22/00277, "Juan de la Cierva-Incorporacion", IJC2018-037897-I, and "Ramon y Cajal" RYC2021-034920-I. We are grateful for financial support from Agencia Estatal de Investigacion (PID2019-111436RBC22/AEI/10.13039/501100011033) and from Generalitat Valenciana through the programs Prometeo CIPROM/2021/003, Equipamiento e Infraestructuras FEDER 2021-22 IDIFEDER/2021/004, Programa de Garantia Juvenil I+D EDGJID/2021/189 and the European Union- Next GenerationEU Programa Investigo INVEST/2022/171. We thank also the Agencia Valencia de la Innovacio for their support through grants INNVA2/2022/11 and METASMART project INNEST/2022/345. Some UK funding was provided by the EPSRC (UKRI) network grant ThUNDDAR. Part of the activities here presented were developed in the framework of the EURAMET, European Association of National Metrology Institutes, 18HLT06 RaCHy Project that received funding from the EMPIR program, European Metrology Programme for Innovation and Research (funder ID: 10.13039/100014132) co-financed by the Participating States and from the European Union's Horizon 2020 research and innovation program. | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | MDPI AG | es_ES |
dc.relation.ispartof | Cancers | es_ES |
dc.rights | Reconocimiento (by) | es_ES |
dc.subject | Acoustic holograms | es_ES |
dc.subject | Acoustic lenses | es_ES |
dc.subject | Ultrasound hyperthermia | es_ES |
dc.subject | Tumor spheroids | es_ES |
dc.subject | Thermal dose | es_ES |
dc.subject.classification | FISICA APLICADA | es_ES |
dc.title | Holographic Focused Ultrasound Hyperthermia System for Uniform Simultaneous Thermal Exposure of Multiple Tumor Spheroids | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.3390/cancers15092540 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-111436RB-C22/ES/NEW TECHNIQUES FOR MULTIMODAL MOLECULAR ELASTOGRAPHIC IMAGING/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/CIENCIA E INNOVACION//RYC2021-034920-I//Convocatoria 2021 de las ayudas Ramón y Cajal de la Agencia Estatal de Investigación. / | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AGENCIA VALENCIANA DE LA INNOVACION//INNVA2%2F2022%2F11//Dispositivos biomédicos de diagnóstico y terapia con tecnologías físicas avanzadas/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AGENCIA VALENCIANA DE LA INNOVACION//INNEST%2F2022%2F345//NUEVA GENERACIÓN DE METASUPERFICIES INTELIGENTES BASADAS EN FABRICACIÓN ADITIVA PARA APLICACIONES ESTRATÉGICAS EN TELECOMUNICACIONES (METASMART)/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AGENCIA ESTATAL DE INVESTIGACION//IJC2018-037897-I//AYUDA JUAN DE LA CIERVA INCORPORACION-JIMENEZ GONZALEZ/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//CIPROM%2F2021%2F003/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//IDIFEDER%2F2021%2F004/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//INVEST%2F2022%2F171/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MCIU//FPU19%2F00601/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MCIU//EST22%2F00277/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ESF//EDGJID%2F2021%2F189/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EURAMET//18HLT06 / | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escuela Politécnica Superior de Gandia - Escola Politècnica Superior de Gandia | es_ES |
dc.description.bibliographicCitation | Andrés, D.; Rivens, I.; Mouratidis, P.; Jimenez, N.; Camarena Femenia, F.; Ter Haar, G. (2023). Holographic Focused Ultrasound Hyperthermia System for Uniform Simultaneous Thermal Exposure of Multiple Tumor Spheroids. Cancers. 15(9). https://doi.org/10.3390/cancers15092540 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/cancers15092540 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 15 | es_ES |
dc.description.issue | 9 | es_ES |
dc.identifier.eissn | 2072-6694 | es_ES |
dc.identifier.pmid | 37174005 | es_ES |
dc.identifier.pmcid | PMC10177503 | es_ES |
dc.relation.pasarela | S\494489 | es_ES |
dc.contributor.funder | European Social Fund | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.contributor.funder | SCIENTIA BIO TECH, S.L. | es_ES |
dc.contributor.funder | AGENCIA ESTATAL DE INVESTIGACION | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación | es_ES |
dc.contributor.funder | AGENCIA VALENCIANA DE LA INNOVACION | es_ES |
dc.contributor.funder | MINISTERIO DE CIENCIA E INNOVACION | es_ES |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades | es_ES |
dc.contributor.funder | European Association of National Metrology Institutes | es_ES |
dc.contributor.funder | Engineering and Physical Sciences Research Council, Reino Unido | es_ES |