Bueno-Palomeque, FL.; Mountris, KA.; Ortigosa, N.; Bailón, R.; Bijnens, B.; Crispi, F.; Pueyo, E.... (2023). QRS-T Angles as Markers for Heart Sphericity in Subjects With Intrauterine Growth Restriction: A Simulation Study. IEEE Journal of Biomedical and Health Informatics. 27(10):4707-4718. https://doi.org/10.1109/JBHI.2023.3297550
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/204069
Título:
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QRS-T Angles as Markers for Heart Sphericity in Subjects With Intrauterine Growth Restriction: A Simulation Study
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Autor:
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Bueno-Palomeque, Freddy L.
Mountris, Konstantinos A.
Ortigosa, Nuria
Bailón, Raquel
Bijnens, Bart
Crispi, Fátima
Pueyo, Esther
Mincholé, Ana
Laguna, Pablo
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Entidad UPV:
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Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials
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Fecha difusión:
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Resumen:
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[EN] Changes induced by intrauterine growth restriction (IUGR) in cardiovascular anatomy and function that persist throughout life have been associated with a higher predisposition to heart disease in adulthood. Together ...[+]
[EN] Changes induced by intrauterine growth restriction (IUGR) in cardiovascular anatomy and function that persist throughout life have been associated with a higher predisposition to heart disease in adulthood. Together with cardiac morphological remodelling, evaluated through the ventricular sphericity index, alterations in cardiac electrical function have been reported by characterization of the depolarization and repolarization loops, and their angular relationship, measured from the vectorcardiogram. The underlying relationship between the morphological remodelling and the angular variation of QRS and T-wave dominant vectors, if any, has not been explored. The aim of this study was to evaluate this relationship using computational models based on realistic heart and torso in which IUGR-induced morphological changes were incorporated by reducing the ventricular sphericity index. Specifically, we departed from a control model and we built eight different globular heart models by reducing the base-to-apex length and enlarging the basal ventricular diameter. We computed QRS and T-wave dominant vectors and angles from simulated pseudo-electrocardiograms and we compared them with clinical measurements. Results for the QRS to T angles follow a change trend congruent with that reported in clinical data, supporting the hypothesis that the IUGR-induced morphological remodelling could contribute to explain the observed angle changes in IUGR patients. By additionally varying the position of the ventricles with respect to the torso and the electrodes, we found that electrode displacement can impact the quantified angles and should be considered when interpreting the results.
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Palabras clave:
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Intrauterine growth restriction
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Cardiac remodelling
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Globular heart
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Sphericity index
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Electrocardiogram
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Derechos de uso:
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Reconocimiento - No comercial - Sin obra derivada (by-nc-nd)
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Fuente:
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IEEE Journal of Biomedical and Health Informatics. (issn:
2168-2194
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DOI:
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10.1109/JBHI.2023.3297550
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Editorial:
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Institute of Electrical and Electronics Engineers
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Versión del editor:
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https://doi.org/10.1109/JBHI.2023.3297550
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Código del Proyecto:
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info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-105674RB-I00/ES/TOWARDS IMPROVED MANAGEMENT OF CARDIOVASCULAR DISEASES BY INTEGRATIVE IN SILICO-IN VITRO-IN VIVO RESEARCH INTO HEART¿S STRUCTURE, FUNCTION AND AUTONOMIC REGULATION/
...[+]
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-105674RB-I00/ES/TOWARDS IMPROVED MANAGEMENT OF CARDIOVASCULAR DISEASES BY INTEGRATIVE IN SILICO-IN VITRO-IN VIVO RESEARCH INTO HEART¿S STRUCTURE, FUNCTION AND AUTONOMIC REGULATION/
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-119457GB-I00/ES/METODOS DEL ANALISIS FUNCIONAL PARA LA TEORIA DE OPERADORES Y EL ANALISIS TIEMPO-FRECUENCIA/
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-128972OA-I00/ES/ESTRATIFICACION DEL RIESGO DE MUERTE SUBITA EN PACIENTES ISQUEMICOS A TRAVES DE LA MORFOLOGIA DEL ECG USANDO LA ARQUITECTURA GENETICA Y MODELOS COMPUTACIONALES/
info:eu-repo/grantAgreement/Gobierno de Aragón//BSICoS T39-20R/
info:eu-repo/grantAgreement/MICINN//TED2021-130459B-I00/
info:eu-repo/grantAgreement/MICINN//RYC2019-027420-I/
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Agradecimientos:
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This work was supported in part by Fundacion Carolina and Universidad Politenica Salesiana, in part by the Spanish Ministry of Science and Innovation (MICINN) and FEDER Una manera de hacer Europa under Grants PID2019-105674RB-I00, ...[+]
This work was supported in part by Fundacion Carolina and Universidad Politenica Salesiana, in part by the Spanish Ministry of Science and Innovation (MICINN) and FEDER Una manera de hacer Europa under Grants PID2019-105674RB-I00, PID2021-128972OA-I00, TED2021-130459B-I00, and PID2020-119457GB-100, through Ramon y Cajal Program under Grant RYC2019-027420-I, in part by the Gobierno de Aragon, Reference Group BSICoS T39-20R, and in part by Project LMP94_21.
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Tipo:
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Artículo
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