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dc.contributor.author | De La Torre, Cristina![]() |
es_ES |
dc.contributor.author | Coll, Carmen![]() |
es_ES |
dc.contributor.author | Ultimo, Amelia![]() |
es_ES |
dc.contributor.author | Sancenón Galarza, Félix![]() |
es_ES |
dc.contributor.author | Martínez-Máñez, Ramón![]() |
es_ES |
dc.contributor.author | Ruiz-Hernández, Eduardo![]() |
es_ES |
dc.date.accessioned | 2024-05-15T18:09:04Z | |
dc.date.available | 2024-05-15T18:09:04Z | |
dc.date.issued | 2023-04 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/204184 | |
dc.description.abstract | [EN] A novel combination of in situ-forming hydrogels of hyaluronic acid with gated mesoporous materials was developed to design depots for local sustained release of chemotherapeutics. The depot consists of a hyaluronic-based gel loaded with redox-responsive mesoporous silica nanoparticles loaded with safranin O or doxorubicin and capped with polyethylene glycol chains containing a disulfide bond. The nanoparticles are able to deliver the payload in the presence of the reducing agent, glutathione (GSH), that promotes the cleavage of the disulfide bonds and the consequent pore opening and cargo delivery. Release studies and cellular assays demonstrated that the depot can successfully liberate the nanoparticles to the media and, subsequently, that the nanoparticles are internalized into the cells where the high concentration of GSH induces cargo delivery. When the nanoparticles were loaded with doxorubicin, a significant reduction in cell viability was observed. Our research opens the way to the development of new depots that enhance the local controlled release of chemotherapeutics by combining the tunable properties of hyaluronic gels with a wide range of gated materials. | es_ES |
dc.description.sponsorship | This research was funded by the Wellcome Trust Institutional Strategic Support Fund, the European Research Council under Grant Agreement No. 758887, and the European Union's Horizon 2020 research and Innovation program under Grant Agreement No. 952259 (NANOFACTS). We also thank the Spanish Government (projects PID2021-126304OB-C41 and PDI2021-122875OB-100) and the Generalitat Valenciana (project PROMETEO CIPROM/2021/007) for support. | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | MDPI AG | es_ES |
dc.relation.ispartof | Pharmaceutics | es_ES |
dc.rights | Reconocimiento (by) | es_ES |
dc.subject | Mesoporous silica | es_ES |
dc.subject | Drug delivery | es_ES |
dc.subject | Molecular gates | es_ES |
dc.subject | In situ-forming gels | es_ES |
dc.subject.classification | QUIMICA ORGANICA | es_ES |
dc.subject.classification | QUIMICA INORGANICA | es_ES |
dc.title | In Situ-Forming Gels Loaded with Stimuli-Responsive Gated Mesoporous Silica Nanoparticles for Local Sustained Drug Delivery | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.3390/pharmaceutics15041071 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-122875OB-I00/ES/NUEVAS ESTRATEGIAS EN LA PREVENCION, DIAGNOSTICO Y TRATAMIENTO DE LAS INFECCIONES ASOCIADAS CON LA ASISTENCIA SANITARIA/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-126304OB-C41/ES/NUEVOS MATERIALES Y SONDAS PARA EL RECONOCIMIENTO, LIBERACION DE FARMACOS, NANOMOTORES Y COMUNICACION/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/758887/EU/REsponsive theranostic nanosystems for Advanced Cancer Treatment/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/952259/EU/Networking Activities for Nanotechnology-Facilitated Cancer Theranostics/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//CIPROM%2F2021%2F007/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials | es_ES |
dc.description.bibliographicCitation | De La Torre, C.; Coll, C.; Ultimo, A.; Sancenón Galarza, F.; Martínez-Máñez, R.; Ruiz-Hernández, E. (2023). In Situ-Forming Gels Loaded with Stimuli-Responsive Gated Mesoporous Silica Nanoparticles for Local Sustained Drug Delivery. Pharmaceutics. 15(4). https://doi.org/10.3390/pharmaceutics15041071 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/pharmaceutics15041071 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 15 | es_ES |
dc.description.issue | 4 | es_ES |
dc.identifier.eissn | 1999-4923 | es_ES |
dc.identifier.pmid | 37111556 | es_ES |
dc.identifier.pmcid | PMC10144720 | es_ES |
dc.relation.pasarela | S\511331 | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación | es_ES |