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dc.contributor.author | Agustí, Ana![]() |
es_ES |
dc.contributor.author | García-Pardo, Maria P.![]() |
es_ES |
dc.contributor.author | López-Almela, Inmaculada![]() |
es_ES |
dc.contributor.author | Campillo, Isabel![]() |
es_ES |
dc.contributor.author | Maes, Michael![]() |
es_ES |
dc.contributor.author | Romaní-Pérez, Marina![]() |
es_ES |
dc.contributor.author | Sanz, Yolanda![]() |
es_ES |
dc.date.accessioned | 2024-05-16T18:08:52Z | |
dc.date.available | 2024-05-16T18:08:52Z | |
dc.date.issued | 2018-03-16 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/204218 | |
dc.description.abstract | [EN] Obesity continues to be one of the major public health problems due to its high prevalence and co-morbidities. Common co-morbidities not only include cardiometabolic disorders but also mood and cognitive disorders. Obese subjects often show deficits in memory, learning and executive functions compared to normal weight subjects. Epidemiological studies also indicate that obesity is associated with a higher risk of developing depression and anxiety, and vice versa. These associations between pathologies that presumably have different etiologies suggest shared pathological mechanisms. Gut microbiota is a mediating factor between the environmental pressures (e.g., diet, lifestyle) and host physiology, and its alteration could partly explain the cross-link between those pathologies. Westernized dietary patterns are known to be a major cause of the obesity epidemic, which also promotes a dysbiotic drift in the gut microbiota; this, in turn, seems to contribute to obesity-related complications. Experimental studies in animal models and, to a lesser extent, in humans suggest that the obesity-associated microbiota may contribute to the endocrine, neurochemical and inflammatory alterations underlying obesity and its comorbidities. These include dysregulation of the HPA-axis with overproduction of glucocorticoids, alterations in levels of neuroactive metabolites (e.g., neurotransmitters, short-chain fatty acids) and activation of a pro-inflammatory milieu that can cause neuro-inflammation. This review updates current knowledge about the role and mode of action of the gut microbiota in the cross-link between energy metabolism, mood and cognitive function. | es_ES |
dc.description.sponsorship | This work and the contract of AA were supported by grant AGL2014-52101-P from the Spanish Ministry of Economy and Competitiveness (MINECO, Spain). The PTA contract of IC and the pre-doctoral scholarship of IL-A from MINECO (Spain) are also fully acknowledged. The contract of MR-P was supported by the EU Project MyNewGut (No. 613979) from the 7th Framework Program. | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | Frontiers Media SA | es_ES |
dc.relation.ispartof | Frontiers in Neuroscience (Online) | es_ES |
dc.rights | Reconocimiento (by) | es_ES |
dc.subject | Behavior | es_ES |
dc.subject | Cognition | es_ES |
dc.subject | Microbiota | es_ES |
dc.subject | Mood | es_ES |
dc.subject | Obesity | es_ES |
dc.title | Interplay Between the Gut-Brain Axis, Obesity and Cognitive Function | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.3389/fnins.2018.00155 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/613979/EU/Microbiome Influence on Energy balance and Brain Development-Function Put into Action to Tackle Diet-related Diseases and Behavior./ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//AGL2014-52101-P/ES/DESCIFRANDO LAS FUNCIONES DEL MICROBIOMA INTESTINAL EN ALTERACIONES METABOLICAS, CONDUCTUALES Y METALES EN ETAPAS CRITICAS DE LA VIDA/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.description.bibliographicCitation | Agustí, A.; García-Pardo, MP.; López-Almela, I.; Campillo, I.; Maes, M.; Romaní-Pérez, M.; Sanz, Y. (2018). Interplay Between the Gut-Brain Axis, Obesity and Cognitive Function. Frontiers in Neuroscience (Online). 12. https://doi.org/10.3389/fnins.2018.00155 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.3389/fnins.2018.00155 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 12 | es_ES |
dc.identifier.eissn | 1662-453X | es_ES |
dc.identifier.pmid | 29615850 | es_ES |
dc.identifier.pmcid | PMC5864897 | es_ES |
dc.relation.pasarela | S\414907 | es_ES |
dc.contributor.funder | Proyecto 7º Programa Marco de la EU | es_ES |
dc.contributor.funder | Ministerio Economía y Competitividad | es_ES |