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dc.contributor.author | Rojas-Vázquez, Sara![]() |
es_ES |
dc.contributor.author | Blasco-Chamarro, Laura![]() |
es_ES |
dc.contributor.author | López-Fabuel, Irene![]() |
es_ES |
dc.contributor.author | Martínez-Máñez, Ramón![]() |
es_ES |
dc.contributor.author | Fariñas, Isabel![]() |
es_ES |
dc.date.accessioned | 2024-05-20T18:08:59Z | |
dc.date.available | 2024-05-20T18:08:59Z | |
dc.date.issued | 2021-04-20 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/204305 | |
dc.description.abstract | [EN] The adult mammalian brain contains distinct neurogenic niches harboring populations of neural stem cells (NSCs) with the capacity to sustain the generation of specific subtypes of neurons during the lifetime. However, their ability to produce new progeny declines with age. The microenvironment of these specialized niches provides multiple cellular and molecular signals that condition NSC behavior and potential. Among the different niche components, vasculature has gained increasing interest over the years due to its undeniable role in NSC regulation and its therapeutic potential for neurogenesis enhancement. NSCs are uniquely positioned to receive both locally secreted factors and adhesion-mediated signals derived from vascular elements. Furthermore, studies of parabiosis indicate that NSCs are also exposed to blood-borne factors, sensing and responding to the systemic circulation. Both structural and functional alterations occur in vasculature with age at the cellular level that can affect the proper extrinsic regulation of NSCs. Additionally, blood exchange experiments in heterochronic parabionts have revealed that age-associated changes in blood composition also contribute to adult neurogenesis impairment in the elderly. Although the mechanisms of vascular- or blood-derived signaling in aging are still not fully understood, a general feature of organismal aging is the accumulation of senescent cells, which act as sources of inflammatory and other detrimental signals that can negatively impact on neighboring cells. This review focuses on the interactions between vascular senescence, circulating pro-senescence factors and the decrease in NSC potential during aging. Understanding the mechanisms of NSC dynamics in the aging brain could lead to new therapeutic approaches, potentially include senolysis, to target age-dependent brain decline. | es_ES |
dc.description.sponsorship | Work in the laboratory of IF is supported by Spanish grants from FEDER/Ministerio de Ciencia e Innovación (MICI)-Agencia Estatal de Investigación (SAF2017-86690-Rand Network of Excellence iDIFFER RED2018-102723-T), Instituto de Salud Carlos III (CIBERNED CB06/05/0086 and RETIC Tercel RD16/0011/0017) and Generalitat Valenciana (Prometeo 2017/030). Work in the laboratory of RM-M is supported by Spanish Government project RTI2018-100910-B-C41 (MCUI/FEDER, EU) and the Generalitat Valenciana project PROMETEO 2018/024. SR-V and LB-C are recipients of predoctoral contracts from the Spanish Ministerio de Educación. IL-F is a recipient of a Juan de la Cierva postdoctoral contract. | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | Frontiers Media SA | es_ES |
dc.relation.ispartof | Frontiers in Neuroscience (Online) | es_ES |
dc.rights | Reconocimiento (by) | es_ES |
dc.subject | Adult neural stem cell | es_ES |
dc.subject | Endothelial cell senescence | es_ES |
dc.subject | Neurogenic niche | es_ES |
dc.subject | Parabiosis | es_ES |
dc.subject | Senescence-associated secretory phenotype | es_ES |
dc.subject.classification | QUIMICA INORGANICA | es_ES |
dc.title | Vascular Senescence: A Potential Bridge Between Physiological Aging and Neurogenic Decline | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.3389/fnins.2021.666881 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-86690-R/ES/REGULACION DEL COMPORTAMIENTO DE LAS CELULAS MADRE NEURALES POR EL MEDIO SISTEMICO: EL NICHO EXTENDIDO/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-100910-B-C41/ES/MATERIALES POROSOS INTELIGENTES MULTIFUNCIONALES Y DISPOSITIVOS ELECTRONICOS PARA LA LIBERACION DE FARMACOS, DETECCION DE DROGAS Y BIOMARCADORES Y COMUNICACION A NANOESCALA/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//RD16%2F0011%2F0017/ES/Red de Terapia Celular (TerCel)/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MSC//CB06%2F05%2F0086/ES/Enfermedades genéticas 86/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//PROMETEO%2F2017%2F030/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//PROMETEO%2F2018%2F024//Sistemas avanzados de liberación controlada/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI//RED2018-102723-T/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials | es_ES |
dc.description.bibliographicCitation | Rojas-Vázquez, S.; Blasco-Chamarro, L.; López-Fabuel, I.; Martínez-Máñez, R.; Fariñas, I. (2021). Vascular Senescence: A Potential Bridge Between Physiological Aging and Neurogenic Decline. Frontiers in Neuroscience (Online). 15. https://doi.org/10.3389/fnins.2021.666881 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.3389/fnins.2021.666881 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 15 | es_ES |
dc.identifier.eissn | 1662-453X | es_ES |
dc.identifier.pmid | 33958987 | es_ES |
dc.identifier.pmcid | PMC8093510 | es_ES |
dc.relation.pasarela | S\448593 | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.contributor.funder | Ministerio de Sanidad y Consumo | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación | es_ES |
dc.contributor.funder | European Regional Development Fund | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad | es_ES |