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The SNR of time-of-flight positron emission tomography data for joint reconstruction of the activity and attenuation images

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The SNR of time-of-flight positron emission tomography data for joint reconstruction of the activity and attenuation images

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dc.contributor.author Nuyts, Johan es_ES
dc.contributor.author Defrise, Michel es_ES
dc.contributor.author Morel, Christian es_ES
dc.contributor.author Lecoq, Paul es_ES
dc.date.accessioned 2024-06-08T19:17:35Z
dc.date.available 2024-06-08T19:17:35Z
dc.date.issued 2024-01-07 es_ES
dc.identifier.issn 0031-9155 es_ES
dc.identifier.uri http://hdl.handle.net/10251/204840
dc.description.abstract [EN] Objective. Measurement of the time-of-flight (TOF) difference of each coincident pair of photons increases the effective sensitivity of positron emission tomography (PET). Many authors have analyzed the benefit of TOF for quantification and hot spot detection in the reconstructed activity images. However, TOF not only improves the effective sensitivity, it also enables the joint reconstruction of the tracer concentration and attenuation images. This can be used to correct for errors in CT- or MR-derived attenuation maps, or to apply attenuation correction without the help of a second modality. This paper presents an analysis of the effect of TOF on the variance of the jointly reconstructed attenuation and (attenuation corrected) tracer concentration images. Approach. The analysis is performed for PET systems that have a distribution of possibly non-Gaussian TOF-kernels, and includes the conventional Gaussian TOF-kernel as a special case. Non-Gaussian TOF-kernels are often observed in novel detector designs, which make use of two (or more) different mechanisms to convert the incoming 511 keV photon to optical photons. The analytical result is validated with a simple 2D simulation. Main results. We show that if two different TOF-kernels are equivalent for image reconstruction with known attenuation, then they are also equivalent for joint reconstruction of the activity and the attenuation images. The variance increase in the activity, caused by also jointly reconstructing the attenuation image, vanishes when the TOF-resolution approaches perfection. Significance. These results are of interest for PET detector development and for the development of stand-alone PET systems. es_ES
dc.description.sponsorship This work was supported in part by the Research Foundation-Flanders (FWO) under Grant G062220N and by NIH/NIBIB grant P41EB017183, CAI2R, New York University. es_ES
dc.language Inglés es_ES
dc.publisher IOP Publishing es_ES
dc.relation.ispartof Physics in Medicine and Biology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject SNR es_ES
dc.subject Positron emission tomography es_ES
dc.subject Reconstruction es_ES
dc.subject Variance es_ES
dc.title The SNR of time-of-flight positron emission tomography data for joint reconstruction of the activity and attenuation images es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1088/1361-6560/ad078c es_ES
dc.relation.projectID info:eu-repo/grantAgreement/FWO//G062220N/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/NIH//1P41EB017183-01A1/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.description.bibliographicCitation Nuyts, J.; Defrise, M.; Morel, C.; Lecoq, P. (2024). The SNR of time-of-flight positron emission tomography data for joint reconstruction of the activity and attenuation images. Physics in Medicine and Biology. 69(1). https://doi.org/10.1088/1361-6560/ad078c es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1088/1361-6560/ad078c es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 69 es_ES
dc.description.issue 1 es_ES
dc.identifier.pmid 37890469 es_ES
dc.identifier.pmcid PMC10811362 es_ES
dc.relation.pasarela S\513733 es_ES
dc.contributor.funder Research Foundation Flanders es_ES
dc.contributor.funder National Institutes of Health, EEUU es_ES


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