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dc.contributor.author | Domínguez-Rodríguez, Marcia![]() |
es_ES |
dc.contributor.author | Meyer, Kathleen![]() |
es_ES |
dc.contributor.author | Sancenón Galarza, Félix![]() |
es_ES |
dc.contributor.author | Blandez, Juan F.![]() |
es_ES |
dc.contributor.author | Serrano, Manuel![]() |
es_ES |
dc.contributor.author | Martínez-Máñez, Ramón![]() |
es_ES |
dc.date.accessioned | 2024-06-14T18:03:28Z | |
dc.date.available | 2024-06-14T18:03:28Z | |
dc.date.issued | 2023-02-23 | es_ES |
dc.identifier.issn | 1359-7345 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/205163 | |
dc.description.abstract | [EN] Kidney damage generates changes at the phenotypic and genotypic levels that allow its monitoring using different biomarkers in blood, urine or serum. Among these biomarkers, kidney failure causes the urine overrepresentation of the alanine aminopeptidase (APN) enzyme. Here, we describe the design of a molecular probe (NB-ALA) based on the Nile Blue fluorophore (NB), which can detect the APN enzyme in urine by simple fluorometric measurements. | es_ES |
dc.description.sponsorship | The authors thank the Spanish Government (PID2021-126304OB-C41) and the Generalitat Valenciana (PROMETEO CIPROM/2021/007) for support and acknowledge the financial support from the FEDER fund of the European Union (IDIFE-DER/2021/044). This work was also supported by CIBER-Consorcio Centro de Investigacion Biomedica en Red-(CB06/01/2012), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovacion. M. D.-R. is grateful for his predoctoral fellowship Grisolias to the Genelalitat Valenciana (GRISOLIAP/2019/144). J. F. B. is thankful for his postdoctoral fellowship Sara Borrell from ISCIII (CD19/00038). | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | The Royal Society of Chemistry | es_ES |
dc.relation.ispartof | Chemical Communications | es_ES |
dc.rights | Reconocimiento (by) | es_ES |
dc.subject | Alanine aminopeptidase | es_ES |
dc.subject | Enzyme | es_ES |
dc.subject | Fluorescent probe | es_ES |
dc.subject | NIR | es_ES |
dc.subject | Renal damage | es_ES |
dc.subject.classification | QUIMICA ORGANICA | es_ES |
dc.subject.classification | QUIMICA INORGANICA | es_ES |
dc.title | A NIR fluorescent probe for the detection of renal damage based on overrepresentation of alanine aminopeptidase enzyme | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1039/D2CC05408F | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-126304OB-C41/ES/NUEVOS MATERIALES Y SONDAS PARA EL RECONOCIMIENTO, LIBERACION DE FARMACOS, NANOMOTORES Y COMUNICACION/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//GRISOLIAP%2F2019%2F144/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//CIPROM%2F2021%2F007/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//IDIFEDER%2F2021%2F044/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII//CD19%2F00038/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/CIBER//CB06%2F01%2F2012/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials | es_ES |
dc.description.bibliographicCitation | Domínguez-Rodríguez, M.; Meyer, K.; Sancenón Galarza, F.; Blandez, JF.; Serrano, M.; Martínez-Máñez, R. (2023). A NIR fluorescent probe for the detection of renal damage based on overrepresentation of alanine aminopeptidase enzyme. Chemical Communications. 59(17):2481-2484. https://doi.org/10.1039/D2CC05408F | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1039/D2CC05408F | es_ES |
dc.description.upvformatpinicio | 2481 | es_ES |
dc.description.upvformatpfin | 2484 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 59 | es_ES |
dc.description.issue | 17 | es_ES |
dc.identifier.pmid | 36752222 | es_ES |
dc.relation.pasarela | S\483547 | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación | es_ES |
dc.contributor.funder | European Regional Development Fund | es_ES |
dc.contributor.funder | Universitat Politècnica de València | es_ES |
dc.contributor.funder | Centro de Investigación Biomédica en Red | es_ES |
dc.contributor.funder | Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina | es_ES |