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Intranasal administration of molecular-gated mesoporous nanoparticles to increase ponatinib delivery to the brain

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Intranasal administration of molecular-gated mesoporous nanoparticles to increase ponatinib delivery to the brain

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dc.contributor.author Sánchez-Dengra, Barbara es_ES
dc.contributor.author Alfonso, María es_ES
dc.contributor.author Gonzalez-Alvarez, Isabel es_ES
dc.contributor.author Bermejo, Marival es_ES
dc.contributor.author Gonzalez -Alvarez, Marta es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.date.accessioned 2024-09-27T18:08:19Z
dc.date.available 2024-09-27T18:08:19Z
dc.date.issued 2023-10 es_ES
dc.identifier.issn 1743-5889 es_ES
dc.identifier.uri http://hdl.handle.net/10251/208929
dc.description.abstract [EN] Background: Glioblastoma is the most common and lethal brain cancer. New treatments are needed. However, the presence of the blood-brain barrier is limiting the development of new treatments directed toward the brain, as it restricts the access and distribution of drugs to the CNS. Materials & methods: In this work, two different nanoparticles (i.e., mesoporous silica nanoparticles and magnetic mesoporous silica nanoparticles) loaded with ponatinib were prepared. Results & conclusion: Both particles were characterized and tested in vitro and in vivo, proving that they are not toxic for blood-brain barrier cells and they increase the amount of drug reaching the brain when administered intranasally in comparison with the results obtained for the free drug. es_ES
dc.description.sponsorship This work was supported, in part, by the project "NUEVA FORMULACION DE PONATINIB PARA EL TRATAMIENTO DEL GLIOMA" funded by FUNDACION BIENVENIDA NAVARRO-LUCIANO TRIPODI and, in part, by the project [PID2021-123888OB-100] funded by Ministry of Science and Innovation from Spain. B Sanchez-Dengra received a grant from the Ministry of Science, Innovation and Universities of Spain (FPU17/00530) and a complementary grant from the Ministry of Science, Innovation and Universities of Spain (EST19/00010). es_ES
dc.language Inglés es_ES
dc.publisher Future Medicine es_ES
dc.relation.ispartof Nanomedicine es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Blood-brain barrier es_ES
dc.subject Glioblastoma es_ES
dc.subject Mesoporous nanoparticles es_ES
dc.subject Ponatinib es_ES
dc.subject Targeted drug delivery es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.title Intranasal administration of molecular-gated mesoporous nanoparticles to increase ponatinib delivery to the brain es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.2217/nnm-2023-0131 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-123888OB-I00/ES/REDUCCION DEL TIEMPO DE DESARROLLO DE ANTIVIRALES ORALES MEDIANTE OPTIMIZACION IN VITRO DE FORMULACIONES: MEDICINAS RAPIDAS, SEGURAS Y BIOEQUIVALENTES./ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MCIU//FPU17%2F00530/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MCIU//EST19%2F00010/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials es_ES
dc.description.bibliographicCitation Sánchez-Dengra, B.; Alfonso, M.; Gonzalez-Alvarez, I.; Bermejo, M.; Gonzalez -Alvarez, M.; Martínez-Máñez, R. (2023). Intranasal administration of molecular-gated mesoporous nanoparticles to increase ponatinib delivery to the brain. Nanomedicine. 18(25):1799-1813. https://doi.org/10.2217/nnm-2023-0131 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.2217/nnm-2023-0131 es_ES
dc.description.upvformatpinicio 1799 es_ES
dc.description.upvformatpfin 1813 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 18 es_ES
dc.description.issue 25 es_ES
dc.identifier.pmid 37990994 es_ES
dc.relation.pasarela S\511352 es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder Ministerio de Ciencia, Innovación y Universidades es_ES


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