Cano-Vicent, A.; Martínez-Agut, A.; Tuñón-Molina, A.; Bakshi, H.; Sabater I Serra, R.; Alfagih, IM.; Serrano-Aroca, Á.... (2023). In vivo and in vitro biocompatible alginate film crosslinked with Ca2+ and Co2+ manifests antiviral, antibacterial and anticancer activity. European Polymer Journal. 197. https://doi.org/10.1016/j.eurpolymj.2023.112377
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/209931
Title:
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In vivo and in vitro biocompatible alginate film crosslinked with Ca2+ and Co2+ manifests antiviral, antibacterial and anticancer activity
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Author:
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Cano-Vicent, Alba
Martínez-Agut, Andrea
Tuñón-Molina, Alberto
Bakshi, Hamid
Sabater i Serra, Roser
Alfagih, Iman M.
Serrano-Aroca, Ángel
Tambuwala, Murtaza M.
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Issued date:
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Abstract:
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[EN] Alginate crosslinked with calcium cations is a promising hydrogel for biomedical applications as it is non-toxic, has suitable mechanical properties and is insoluble in water. Cobalt has been shown to possess antibacterial ...[+]
[EN] Alginate crosslinked with calcium cations is a promising hydrogel for biomedical applications as it is non-toxic, has suitable mechanical properties and is insoluble in water. Cobalt has been shown to possess antibacterial capacity against Gram-positive and Gram-negative bacteria, and has an angiogenesis effect. In this study, alginate films were crosslinked with Ca2+ and Co2+ ions to explore their biological properties in terms of antiviral capacity, antibacterial properties, anticancer activity and their toxicity. The results show that the hydrogel with a very small amount of cobalt was biocompatible in vivo using the Caenorhabditis elegans model and in vitro on human keratinocyte cells and it also exhibited antibacterial activity against the life-threatening methicillinresistant Staphylococcus aureus. Furthermore, this hydrogel showed antiviral activity against a surrogate of SARSCoV-2 and anticancer properties against melanoma and colon cancer cells, which render it a promising material for biomedical applications such as wound healing and tissue engineering. Water sorption experiments, Fourier transform infrared spectroscopy, electron microscopy with Energy Dispersive X-ray Spectrometry and degradation analysis in acid aqueous medium were performed to complete the characterization of these new materials.
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Subjects:
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Alginate
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Cobalt
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Toxicity
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Antiviral
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Antibacterial
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Anticancer
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Copyrigths:
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Reconocimiento (by)
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Source:
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European Polymer Journal. (issn:
0014-3057
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DOI:
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10.1016/j.eurpolymj.2023.112377
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Publisher:
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Elsevier
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Publisher version:
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https://doi.org/10.1016/j.eurpolymj.2023.112377
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Project ID:
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info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-119333RB-I00/ES/SOPORTES BIOFUNCIONALES CON CAPACIDAD OSTEOINDUCTORA Y ANTIMICROBIANA PARA INGENIERIA TISULAR OSEA/
info:eu-repo/grantAgreement/ISCIII//CIBER-BBN/
info:eu-repo/grantAgreement/KSU//RSP-2023R782/
info:eu-repo/grantAgreement/UCV//2020-231-006UCV/
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Thanks:
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The authors would like to express their gratitude to the Fundacion Universidad Catolica de Valencia San Vicente Martir and to the Spanish Ministry of Science and Innovation for their financial support through Grant ...[+]
The authors would like to express their gratitude to the Fundacion Universidad Catolica de Valencia San Vicente Martir and to the Spanish Ministry of Science and Innovation for their financial support through Grant 2020-231-006UCV and PID2020-119333RB-I00 / AEI / 10.13039/501100011033, respectively. The CIBER-BBN initiative is funded by the VI National R&D&I Plan 2008 - 2011, Iniciativa Ingenio 2010, Consolider Program. CIBER actions are financed by the Instituto de Salud Carlos III with assistance from the European Regional Development. Funding support also from Researchers Supporting Project number (RSP-2023R782), King Saud University, Riyadh, Saudi Arabia.
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Type:
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Artículo
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