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Water-assisted synthesis of stable and multicolored CsPbX3@SiO2 core shell nanoparticles as fluorescent probes for biosensing

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Water-assisted synthesis of stable and multicolored CsPbX3@SiO2 core shell nanoparticles as fluorescent probes for biosensing

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dc.contributor.author Collantes-Pablo, Cynthia es_ES
dc.contributor.author Teixeira, William es_ES
dc.contributor.author González-Pedro, Victoria es_ES
dc.contributor.author Bañuls Polo, María-José es_ES
dc.contributor.author Quintero-Campos, Pedro es_ES
dc.contributor.author Morais, Sergi es_ES
dc.contributor.author Maquieira Catala, Angel es_ES
dc.date.accessioned 2024-10-30T19:01:17Z
dc.date.available 2024-10-30T19:01:17Z
dc.date.issued 2023-11-15 es_ES
dc.identifier.issn 1477-9226 es_ES
dc.identifier.uri http://hdl.handle.net/10251/211077
dc.description.abstract [EN] Colloidal lead halide perovskite nanocrystals are highly luminescent materials with great promise as fluorescent probes in biosensing as long as their intrinsic instability in aqueous media is effectively addressed. In this study, we successfully prepared stable and multicolored CsPbX3@SiO2 (X = Cl/Br, Br and I) core¿ shell nanoparticles through a simple method based on the water-induced transformation of Cs4PbX6 into CsPbX3, combined with sol¿gel procedures. We observed that the concentration of the Cs4PbX6 precursor plays a crucial role in the formation of isolated nanospheres with uniform silica coating and in controlling the number of core-free particles. Furthermore, our research expands this approach to other halide compositions, resulting in multicolored core¿shell nanoparticles with emission wavelengths ranging from 490 to 700 nm, average sizes below 30 nm, and photoluminescence quantum yields close to 60%. Unlike in previous reports, the silica coating boosts the photoluminescence quantum yields compared to uncoated counterparts and provides increased structural stability for more than four days. Moreover, a controlled thermal treatment confers water stability to the as-synthesized nanoparticles. To establish the feasibility of the developed materials as fluorescent probes, we successfully demonstrated their specific recognition of a humanized antibody (omalizumab) used in treating patients with severe allergic asthma. This work paves the way to develop in vitro tests using CsPbX3@SiO2 core¿shell nanoparticles as fluorogenic probes. es_ES
dc.description.sponsorship This work was financially supported by the E.U FEDER project ADBIHOL/AEI/10.13039/501100011033 from MCIN/AEI and PROMETEO/2020/094 from Generalitat Valenciana. C. C. thanks the Spanish Ministry of Economy and Competitiveness for her predoctoral contract (BES-2017-080242). W. T. acknowledges the financial support from Universitat Politécnica de Valéncia for the Ph.D. studies (PAID-01-19-06). es_ES
dc.language Inglés es_ES
dc.publisher The Royal Society of Chemistry es_ES
dc.relation.ispartof Dalton Transactions es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Water-assisted synthesis es_ES
dc.subject Core shell nanoparticles es_ES
dc.subject Isolated nanospheres es_ES
dc.subject Photoluminescence es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.title Water-assisted synthesis of stable and multicolored CsPbX3@SiO2 core shell nanoparticles as fluorescent probes for biosensing es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1039/D3DT02593D es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-110713RB-I00/ES/HACIA EL BIOSENSADO HOLOGRAFICO AVANZADO/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/UPV-VIN//PAID-01-19-06//Explorando las nanopartículas de perovskita de haluros metálicos como elementos de biosensado: desde agentes de contraste fluorescentes hasta transductores ópticos./ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GENERALITAT VALENCIANA//PROMETEO%2F2020%2F094//HOLOGRAFÍA. UNA VIA PARA AFRONTAR NUEVOS RETOS EN BIOSENSADO/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI//BES-2017-080242//AYUDAS PARA CONTRATOS PREDOCTORALES PARA LA FORMACION DE DOCTORES-COLLANTES PABLO/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural es_ES
dc.description.bibliographicCitation Collantes-Pablo, C.; Teixeira, W.; González-Pedro, V.; Bañuls Polo, M.; Quintero-Campos, P.; Morais, S.; Maquieira Catala, A. (2023). Water-assisted synthesis of stable and multicolored CsPbX3@SiO2 core shell nanoparticles as fluorescent probes for biosensing. Dalton Transactions. (48):18464-18472. https://doi.org/10.1039/D3DT02593D es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1039/D3DT02593D es_ES
dc.description.upvformatpinicio 18464 es_ES
dc.description.upvformatpfin 18472 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.issue 48 es_ES
dc.identifier.pmid 38013493 es_ES
dc.relation.pasarela S\505265 es_ES
dc.contributor.funder GENERALITAT VALENCIANA es_ES
dc.contributor.funder AGENCIA ESTATAL DE INVESTIGACION es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder UNIVERSIDAD POLITECNICA DE VALENCIA es_ES


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