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Osteogenic differentiation of human mesenchymal stem cells on electroactive substrates

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Osteogenic differentiation of human mesenchymal stem cells on electroactive substrates

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dc.contributor.author Tamaño-Machiavello, María Noel es_ES
dc.contributor.author Carvalho, E.O. es_ES
dc.contributor.author Correia, Daniela es_ES
dc.contributor.author Cordón, Lourdes es_ES
dc.contributor.author Lanceros-Méndez, Senentxu es_ES
dc.contributor.author Sempere, Amparo es_ES
dc.contributor.author Sabater i Serra, Roser es_ES
dc.contributor.author Gómez Ribelles, José Luís es_ES
dc.date.accessioned 2024-11-13T19:12:55Z
dc.date.available 2024-11-13T19:12:55Z
dc.date.issued 2024-03-29 es_ES
dc.identifier.uri http://hdl.handle.net/10251/211722
dc.description.abstract [EN] This study investigates the effect of electroactivity and electrical charge distribution on the biological response of human bone marrow stem cells (hBMSCs) cultured in monolayer on flat poly(vinylidene fluoride), PVDF, substrates. Differences in cell behaviour, including proliferation, expression of multipotency markers CD90, CD105 and CD73, and expression of genes characteristic of different mesenchymal lineages, were observed both during expansion in basal medium before reaching confluence and in confluent cultures in osteogenic induction medium. The crystallisation of PVDF in the electrically neutral ¿-phase or in the electroactive phase ß, both unpoled and poled, has been found to have an important influence on the biological response. In addition, the presence of a permanent positive or negative surface electrical charge distribution in phase ß substrates has also shown a significant effect on cell behaviour. es_ES
dc.description.sponsorship This work has been supported by PID2022-138572OB-C41 and C42 projects funded by MCIN/AEI/10.13039/501100011033/ FEDER, Spain/EU. The research was also supported by CIBER Consorcio Centro de Investigacion Biomedica en Red - CB06/01/1026, Instituto de Salud Carlos III (Ministerio de Ciencia e Innovacion, Spain), and by the Portuguese Foundation for Science and Technology (FCT) under strategic funding UID/FIS/04650/2021, grant SFRH/BD/145455/2019 (EOC) and Investigator FCT Contract 2020.02915.CEECIND (D.M.C.). Support from the Basque Government Industry Department under the ELKARTEK program is also acknowledged. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Heliyon es_ES
dc.rights Reconocimiento - No comercial (by-nc) es_ES
dc.subject Poly(vinylidene fluoride) es_ES
dc.subject Electroactive cell substrates es_ES
dc.subject Human bone marrow mesenchymal cells es_ES
dc.subject Multipotency markers es_ES
dc.subject.classification INGENIERIA ELECTRICA es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Osteogenic differentiation of human mesenchymal stem cells on electroactive substrates es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.heliyon.2024.e28880 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-138572OB-C41/ES/MICROENTORNO ADAPTATIVO DINAMICAMENTE PARA LA REGENERACION TISULAR/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-138572OB-C42/ES/MICROENTORNO ADAPTATIVO PARA LA REGENERACION DE MEDULA ESPINAL/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MSC//CB06%2F01%2F1026/ES/Desarrollo e implementación de nuevas tecnologías en biomedicina 106/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/FCT//UID%2FFIS%2F04650%2F2021/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/FCT//2020.02915.CEECIND/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F145455%2F2019/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials es_ES
dc.description.bibliographicCitation Tamaño-Machiavello, MN.; Carvalho, E.; Correia, D.; Cordón, L.; Lanceros-Méndez, S.; Sempere, A.; Sabater I Serra, R.... (2024). Osteogenic differentiation of human mesenchymal stem cells on electroactive substrates. Heliyon. 10. https://doi.org/10.1016/j.heliyon.2024.e28880 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.heliyon.2024.e28880 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 10 es_ES
dc.identifier.eissn 2405-8440 es_ES
dc.identifier.pmid 38601667 es_ES
dc.identifier.pmcid PMC11004758 es_ES
dc.relation.pasarela S\517918 es_ES
dc.contributor.funder Eusko Jaurlaritza es_ES
dc.contributor.funder Ministerio de Sanidad y Consumo es_ES
dc.contributor.funder AGENCIA ESTATAL DE INVESTIGACION es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder Fundação para a Ciência e a Tecnologia, Portugal es_ES
upv.costeAPC 2057 es_ES


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