C-N Coupling of Indoles and Carbazoles with Aromatic Chlorides Catalyzed by a Single-Component NHC-Nickel(0) Precursor
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https://riunet.upv.es/handle/10251/214308
Cita bibliográfica
G. Rull, S.; Blandez, JF.; R. Fructos, M.; R. Belderrain, T.; Nicasio, MC. (2015). C-N Coupling of Indoles and Carbazoles with Aromatic Chlorides Catalyzed by a Single-Component NHC-Nickel(0) Precursor. Advanced Synthesis & Catalysis. 357(5):907-911. https://doi.org/10.1002/adsc.201500030
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A new and efficient nickel-based protocol for the N-arylation of indoles and carbazoles with aromatic chlorides, the least expensive of the aryl halides, is described. The procedure provides selectively N-(hetero)arylation products in good to high yields, in short reaction times and without adding an excess of ligands.
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Advanced Synthesis & Catalysis issn: 1615-4150