Upconversion nanohybrids for NIR-induced photorepair of DNA etheno adducts
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https://riunet.upv.es/handle/10251/224390
Cita bibliográfica
Francés-Soriano, Laura; Rodríguez Muñiz, Gemma María; Lizondo-Aranda, P.; Bellezza, D.; González-Béjar, M.; Lhiaubet, Virginie Lyria (2025). Upconversion nanohybrids for NIR-induced photorepair of DNA etheno adducts. Nanoscale. https://doi.org/10.1039/d5nr01777g
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[EN] Here, we report NIR-triggered photorepair of DNA damages via photosensitization by using well-known upconversion nanohybrids consisting of ytterbium and erbium co-doped core-shell upconversion nanoparticles (UCs) and Rose Bengal (UC@RB). Specifically, two purine-derived etheno adducts (1,N6-etheno-2 '-deoxyadenosine (epsilon dA) and 1,N2-etheno-2 '-deoxyguanosine (epsilon dG)) have been used as proof of concept.
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Nanoscale issn: 2040-3364