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Modeling of the Role of Conformational Dynamics in Kinetics of the Antigen−Antibody Interaction in Heterogeneous Phase

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Modeling of the Role of Conformational Dynamics in Kinetics of the Antigen−Antibody Interaction in Heterogeneous Phase

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Giménez Romero, D.; González Martínez, MÁ.; Bañuls Polo, MJ.; Monzó, IS.; Puchades Pla, R.; Maquieira Catala, Á. (2012). Modeling of the Role of Conformational Dynamics in Kinetics of the Antigen−Antibody Interaction in Heterogeneous Phase. Journal of Physical Chemistry B. 116:5679-5688. doi:10.1021/jp301953z

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/28274

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Title: Modeling of the Role of Conformational Dynamics in Kinetics of the Antigen−Antibody Interaction in Heterogeneous Phase
Author: Giménez Romero, David González Martínez, Miguel Ángel Bañuls Polo, Mª José Monzó, Isidro S. Puchades Pla, Rosa Maquieira Catala, Ángel
UPV Unit: Universitat Politècnica de València. Departamento de Química - Departament de Química
Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic
Issued date:
Abstract:
[EN] A novel approach that may potentially be used to study biomolecular interactions including the simultaneous determination of structural and kinetic binding parameters is described in this Article for the first time. ...[+]
Subjects: Antigen binding , Antigen-antibody interaction , Binding process , Biomolecular interactions , Biomolecular recognition , Bovine serum albumins , BSA molecules , Conformational dynamics , Conformational selection , Heterogeneous phase , Immunoglobulin G , In-situ , Induced fit , Kinetic binding , Reaction mechanism , Reaction schemes , Sensing surface , Silicon chip , Simultaneous determinations , Steric hindrances , Structural aspects , Antigens , Conformations , Molecular recognition , Molecules , Rate constants , X ray crystallography , Antibodies
Copyrigths: Cerrado
Source:
Journal of Physical Chemistry B. (issn: 1520-6106 )
DOI: 10.1021/jp301953z
Publisher:
American Chemical Society
Publisher version: http://pubs.acs.org/doi/pdf/10.1021/jp301953z
Thanks:
This research was funded through project Feder CTQ2010-15943 (CICYT, Spain), GVA ACOMP-2009/650, and GVA Prometeo 2010/008. D.G.-R. acknowledges his position in the "Ramon y Cajal" Program (Spanish Ministry of Economy and ...[+]
Type: Artículo

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