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Design of enzyme-mediated controlled release systems based on silica mesoporous supports capped with ester-glycol groups

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Design of enzyme-mediated controlled release systems based on silica mesoporous supports capped with ester-glycol groups

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Agostini, A.; Mondragón Martínez, L.; Pascual Vidal, L.; Aznar Gimeno, E.; Coll Merino, MC.; Martínez Mañez, R.; Sancenón Galarza, F.... (2012). Design of enzyme-mediated controlled release systems based on silica mesoporous supports capped with ester-glycol groups. Langmuir. 28:14766-14776. doi:10.1021/la303161e.

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/28283

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Título: Design of enzyme-mediated controlled release systems based on silica mesoporous supports capped with ester-glycol groups
Autor:
Entidad UPV: Universitat Politècnica de València. Departamento de Química - Departament de Química
Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic
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Resumen:
[EN] An ethylene glycol-capped hybrid material for the controlled release of molecules in the presence of esterase enzyme has been prepared. The final organic-inorganic hybrid solid S1 was synthesized by a two-step procedure. ...[+]
Palabras clave: Aqueous suspensions , Camptothecin (CPT) , Cell internalization , Cell viability , Controlled release , Controlled release systems , Cytotoxic drugs , Enzyme-mediated hydrolysis , Ester bonds , Esterase enzymes , Functionalized , Glycol derivatives , MCF-7 cells , MCM-41 supports , Mesoporous support , Molecular cap , Molecular gates , Oligo(ethylene glycol) , Organic-inorganic hybrid solids , Ruthenium complexes , Size reductions , Steric hindrances , Therapeutic Application , Two-step procedure , Body fluids , Cell culture , Cell death , Chlorine compounds , Confocal microscopy , Cytotoxicity , Enzymatic hydrolysis , Esterification , Ethylene glycol , Hybrid materials , Nanoparticles , Ruthenium , Ruthenium compounds , Silica , Suspensions (fluids) , Esters
Derechos de uso: Cerrado
Fuente:
Langmuir. (issn: 0743-7463 )
DOI: 10.1021/la303161e
Editorial:
American Chemical Society
Versión del editor: http://pubs.acs.org/doi/pdf/10.1021/la303161e
Patrocinador:
Spanish Government (Projects MAT2009
Generalitat Valencia (Project PROMETEO/2009
Tipo: Artículo

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