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Design of enzyme-mediated controlled release systems based on silica mesoporous supports capped with ester-glycol groups

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Design of enzyme-mediated controlled release systems based on silica mesoporous supports capped with ester-glycol groups

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Agostini, A.; Mondragón Martínez, L.; Pascual Vidal, L.; Aznar Gimeno, E.; Coll Merino, MC.; Martínez Mañez, R.; Sancenón Galarza, F.... (2012). Design of enzyme-mediated controlled release systems based on silica mesoporous supports capped with ester-glycol groups. Langmuir. 28:14766-14776. doi:10.1021/la303161e

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/28283

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Title: Design of enzyme-mediated controlled release systems based on silica mesoporous supports capped with ester-glycol groups
Author:
UPV Unit: Universitat Politècnica de València. Departamento de Química - Departament de Química
Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic
Issued date:
Abstract:
[EN] An ethylene glycol-capped hybrid material for the controlled release of molecules in the presence of esterase enzyme has been prepared. The final organic-inorganic hybrid solid S1 was synthesized by a two-step procedure. ...[+]
Subjects: Aqueous suspensions , Camptothecin (CPT) , Cell internalization , Cell viability , Controlled release , Controlled release systems , Cytotoxic drugs , Enzyme-mediated hydrolysis , Ester bonds , Esterase enzymes , Functionalized , Glycol derivatives , MCF-7 cells , MCM-41 supports , Mesoporous support , Molecular cap , Molecular gates , Oligo(ethylene glycol) , Organic-inorganic hybrid solids , Ruthenium complexes , Size reductions , Steric hindrances , Therapeutic Application , Two-step procedure , Body fluids , Cell culture , Cell death , Chlorine compounds , Confocal microscopy , Cytotoxicity , Enzymatic hydrolysis , Esterification , Ethylene glycol , Hybrid materials , Nanoparticles , Ruthenium , Ruthenium compounds , Silica , Suspensions (fluids) , Esters
Copyrigths: Cerrado
Source:
Langmuir. (issn: 0743-7463 )
DOI: 10.1021/la303161e
Publisher:
American Chemical Society
Publisher version: http://pubs.acs.org/doi/pdf/10.1021/la303161e
Thanks:
We thank the Spanish Government (Projects MAT2009-14564-C04 and SAF2010-15512) and the Generalitat Valencia (Project PROMETEO/2009/016) for support. A.A. and L.M. thank the Generalitat Valenciana for their Santiago Grisolia ...[+]
Type: Artículo

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