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Design of enzyme-mediated controlled release systems based on silica mesoporous supports capped with ester-glycol groups

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Design of enzyme-mediated controlled release systems based on silica mesoporous supports capped with ester-glycol groups

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Agostini, A.; Mondragón Martínez, L.; Pascual Vidal, L.; Aznar Gimeno, E.; Coll Merino, MC.; Martínez Mañez, R.; Sancenón Galarza, F.... (2012). Design of enzyme-mediated controlled release systems based on silica mesoporous supports capped with ester-glycol groups. Langmuir. 28:14766-14776. https://doi.org/10.1021/la303161e

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/28283

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Title: Design of enzyme-mediated controlled release systems based on silica mesoporous supports capped with ester-glycol groups
Author: Agostini, Alessandro Mondragón Martínez, Laura Pascual Vidal, Lluís Aznar Gimeno, Elena Coll Merino, Mª Carmen Martínez Mañez, Ramón Sancenón Galarza, Félix Soto Camino, Juan Marcos Martínez, María Dolores Amoros del Toro, Pedro Costero, Ana M. Parra, Margarita Gil, Salvador
UPV Unit: Universitat Politècnica de València. Departamento de Química - Departament de Química
Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic
Issued date:
Abstract:
[EN] An ethylene glycol-capped hybrid material for the controlled release of molecules in the presence of esterase enzyme has been prepared. The final organic-inorganic hybrid solid S1 was synthesized by a two-step procedure. ...[+]
Subjects: Aqueous suspensions , Camptothecin (CPT) , Cell internalization , Cell viability , Controlled release , Controlled release systems , Cytotoxic drugs , Enzyme-mediated hydrolysis , Ester bonds , Esterase enzymes , Functionalized , Glycol derivatives , MCF-7 cells , MCM-41 supports , Mesoporous support , Molecular cap , Molecular gates , Oligo(ethylene glycol) , Organic-inorganic hybrid solids , Ruthenium complexes , Size reductions , Steric hindrances , Therapeutic Application , Two-step procedure , Body fluids , Cell culture , Cell death , Chlorine compounds , Confocal microscopy , Cytotoxicity , Enzymatic hydrolysis , Esterification , Ethylene glycol , Hybrid materials , Nanoparticles , Ruthenium , Ruthenium compounds , Silica , Suspensions (fluids) , Esters
Copyrigths: Cerrado
Source:
Langmuir. (issn: 0743-7463 )
DOI: 10.1021/la303161e
Publisher:
American Chemical Society
Publisher version: http://pubs.acs.org/doi/pdf/10.1021/la303161e
Project ID:
Spanish Government (Projects MAT2009
Generalitat Valencia (Project PROMETEO/2009
Thanks:
We thank the Spanish Government (Projects MAT2009-14564-C04 and SAF2010-15512) and the Generalitat Valencia (Project PROMETEO/2009/016) for support. A.A. and L.M. thank the Generalitat Valenciana for their Santiago Grisolia ...[+]
Type: Artículo

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