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Site-dependent photo-fries rearrangement within serum albumins

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Site-dependent photo-fries rearrangement within serum albumins

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dc.contributor.author Marín Melchor, Mireia es_ES
dc.contributor.author Lhiaubet ., Virginie Lyria es_ES
dc.contributor.author Miranda Alonso, Miguel Ángel es_ES
dc.date.accessioned 2013-04-29T13:40:07Z
dc.date.issued 2011-03-08
dc.identifier.issn 1520-6106
dc.identifier.uri http://hdl.handle.net/10251/28318
dc.description.abstract [EN] : In the present work, the in¿uence of serum albumins as biological hosts on the well-established photo-Fries rearrangement has been investigated. For this purpose, 4-methoxy-1-naphthyl hydrogen succinate and glutarate (1a,b) as well as the corresponding acetate (1c), have been selected as substrates. Special attention has been devoted to the e¿ect of the binding site location and serum albumin species on the outcome of the reaction. In a ¿rst stage, the stabilizing e¿ect of the biomacromolecule on the intramolecularly catalyzed hydrolysis of succinate 1a was observed. Then, 1b and 1c were considered for their interaction with proteins in site II and site I, respectively. Site assignment was con¿rmed by ¿uorescence displacement experiments with dansylamide and dansylglycine. More- over, spectroscopic analysis showed a site dependent quantum yield of product formation for human and bovine serum albumin. es_ES
dc.description.sponsorship Spanish Government (CTQ2009-13699 project, Ramon y Cajal contract to V.L.-V. and JAE predoc contract to MM.), Generalitat Valenciana (Prometeo Program 2008/090 and GV/2009/051 projects) and Universidad Politecnica de Valencia (PAID 06-08 project) are gratefully acknowledged for financial support. en_EN
dc.language Inglés es_ES
dc.publisher American Chemical Society es_ES
dc.relation.ispartof Journal of Physical Chemistry B es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.title Site-dependent photo-fries rearrangement within serum albumins es_ES
dc.type Artículo es_ES
dc.embargo.lift 10000-01-01
dc.embargo.terms forever es_ES
dc.identifier.doi 10.1021/jp2009463
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//CTQ2009-13699/ES/MECANISMOS FOTOQUIMICOS DEL DAÑO AL ADN Y SU REPARACION. FOTOSENSIBILIZACION FRENTE A FOTOPROTECCION/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Generalitat Valenciana//GV%2F2009%2F051/ES/Las albuminas como fotobiocatalizadores supramoleculares/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química es_ES
dc.description.bibliographicCitation Marín Melchor, M.; Lhiaubet ., VL.; Miranda Alonso, MÁ. (2011). Site-dependent photo-fries rearrangement within serum albumins. Journal of Physical Chemistry B. 115:2910-2915. https://doi.org/10.1021/jp2009463 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://pubs.acs.org/doi/pdf/10.1021/jp2009463 es_ES
dc.description.upvformatpinicio 2910 es_ES
dc.description.upvformatpfin 2915 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 115 es_ES
dc.relation.senia 192952
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES


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