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Simulation and Mechanistic Investigation of the Arrhythmogenic Role of the Late Sodium Current in Human Heart Failure

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Simulation and Mechanistic Investigation of the Arrhythmogenic Role of the Late Sodium Current in Human Heart Failure

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Trenor Gomis, BA.; Cardona Urrego, KE.; Gómez García, JF.; Rajamani, S.; Ferrero De Loma-Osorio, JM.; Belardinelli, L.; Saiz Rodríguez, FJ. (2012). Simulation and Mechanistic Investigation of the Arrhythmogenic Role of the Late Sodium Current in Human Heart Failure. PLoS ONE. 7(3):1-12. doi:10.1371/journal.pone.0032659

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/28574

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Title: Simulation and Mechanistic Investigation of the Arrhythmogenic Role of the Late Sodium Current in Human Heart Failure
Author:
UPV Unit: Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica
Universitat Politècnica de València. Instituto Interuniversitario de Investigación en Bioingeniería y Tecnología Orientada al Ser Humano - Institut Interuniversitari d'Investigació en Bioenginyeria i Tecnologia Orientada a l'Ésser Humà
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Abstract:
Heart failure constitutes a major public health problem worldwide. The electrophysiological remodeling of failing hearts sets the stage for malignant arrhythmias, in which the role of the late Na + current (I NaL) is ...[+]
Subjects: Adenosine triphosphatase (potassium sodium) , Calcium ion , Ion channel , Sodium calcium exchange protein , Sodium , Arrhythmogenesis , Article , Calcium homeostasis , Controlled study , Electrophysiology , Enzyme regulation , Heart failure , Heart muscle cell , Heart muscle potential , Human , Human cell , Phenotype , Protein expression , Protein function , Sensitivity analysis , Sodium current , Action potential , Biological model , Computer simulation , Cytology , Heart arrhythmia , Heart ventricle , Heart ventricle remodeling , Metabolism , Muscle cell , Pathophysiology , Physiology , Action Potentials , Arrhythmias, Cardiac , Heart Ventricles , Humans , Models, Cardiovascular , Muscle Cells , Sodium-Calcium Exchanger , Sodium-Potassium-Exchanging ATPase , Ventricular Remodeling
Copyrigths: Reconocimiento (by)
Source:
PLoS ONE. (issn: 1932-6203 )
DOI: 10.1371/journal.pone.0032659
Publisher:
Public Library of Science
Publisher version: http://dx.doi.org/10.1371/journal.pone.0032659
Project ID: info:eu-repo/grantAgreement/EC/FP7/224381/EU
Thanks:
This work was partially supported by the European Commission preDiCT grant (DG-INFSO-224381), by the Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica del Ministerio de Ciencia e Innovacion of ...[+]
Type: Artículo

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