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Development of a Mass Sensitive Quartz Crystal Microbalance (QCM)-Based DNA Biosensor Using a 50 MHz Electronic Oscillator Circuit,

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Development of a Mass Sensitive Quartz Crystal Microbalance (QCM)-Based DNA Biosensor Using a 50 MHz Electronic Oscillator Circuit,

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dc.contributor.author García-Martinez, Gonzalo es_ES
dc.contributor.author Alonso Bustabad, Enrique es_ES
dc.contributor.author Perrot, Hubert es_ES
dc.contributor.author Gabrielli, Claude es_ES
dc.contributor.author Bucur, Bogdan es_ES
dc.contributor.author Lazerges, Mathieu es_ES
dc.contributor.author Rose, Daniel es_ES
dc.contributor.author Rodriguez-Pardo, Loreto es_ES
dc.contributor.author Fariña Tojo, Jose es_ES
dc.contributor.author Compère, Chantal es_ES
dc.contributor.author Arnau Vives, Antonio
dc.date.accessioned 2013-05-09T11:45:36Z
dc.date.available 2013-05-09T11:45:36Z
dc.date.issued 2011
dc.identifier.issn 1424-8220
dc.identifier.uri http://hdl.handle.net/10251/28713
dc.description.abstract This work deals with the design of a high sensitivity DNA sequence detector using a 50 MHz quartz crystal microbalance (QCM) electronic oscillator circuit. The oscillator circuitry is based on Miller topology, which is able to work in damping media. Calibration and experimental study of frequency noise are carried out, finding that the designed sensor has a resolution of 7.1 ng/cm 2 in dynamic conditions (with circulation of liquid). Then the oscillator is proved as DNA biosensor. Results show that the system is able to detect the presence of complementary target DNAs in a solution with high selectivity and sensitivity. DNA target concentrations higher of 50 ng/mL can be detected. © 2011 by the authors; licensee MDPI, Basel, Switzerland. es_ES
dc.description.sponsorship ANR PRECODD (HAB SEACHIP) and Erasmus Program (European Union) are gratefully acknowledged for financially supporting this research. en_EN
dc.language Inglés es_ES
dc.publisher MDPI es_ES
dc.relation.ispartof Sensors es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject DNA sequence detection es_ES
dc.subject Electronic oscillator es_ES
dc.subject Frequency noise es_ES
dc.subject Quartz crystal microbalance es_ES
dc.subject Resolution es_ES
dc.subject Sensitivity es_ES
dc.subject Disulfide es_ES
dc.subject DNA es_ES
dc.subject Article es_ES
dc.subject Calibration es_ES
dc.subject Chemistry es_ES
dc.subject Electrochemistry es_ES
dc.subject Electronics es_ES
dc.subject Equipment design es_ES
dc.subject Genetic procedures es_ES
dc.subject Methodology es_ES
dc.subject Oscillometry es_ES
dc.subject Physics es_ES
dc.subject Reproducibility es_ES
dc.subject Biosensing Techniques es_ES
dc.subject Disulfides es_ES
dc.subject Quartz Crystal Microbalance Techniques es_ES
dc.subject Reproducibility of Results es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Development of a Mass Sensitive Quartz Crystal Microbalance (QCM)-Based DNA Biosensor Using a 50 MHz Electronic Oscillator Circuit, es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/s110807656
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.description.bibliographicCitation García-Martinez, G.; Alonso Bustabad, E.; Perrot, H.; Gabrielli, C.; Bucur, B.; Lazerges, M.; Rose, D.... (2011). Development of a Mass Sensitive Quartz Crystal Microbalance (QCM)-Based DNA Biosensor Using a 50 MHz Electronic Oscillator Circuit,. Sensors. 11:7656-7664. doi:10.3390/s110807656 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://www.mdpi.com/1424-8220/11/8/7656 es_ES
dc.description.upvformatpinicio 7656 es_ES
dc.description.upvformatpfin 7664 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 11 es_ES
dc.relation.senia 220301
dc.identifier.pmid 22164037 en_EN
dc.identifier.pmcid PMC3231718 en_EN
dc.contributor.funder European Commission es_ES
dc.contributor.funder Agence Nationale de la Recherche, Francia es_ES


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