Martínez Climent, BA.; Guillem Sánchez, MS.; Zhang, Y.; Millet Roig, J.; Mazgalev, TN. (2011). Functional Mathematical Model of Dual Pathway AV nodal Conduction. AJP - Heart and Circulatory Physiology. 300(4):1393-1401. https://doi.org/10.1152/ajpheart.01175.2010
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/30031
Title:
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Functional Mathematical Model of Dual Pathway AV nodal Conduction
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Author:
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Martínez Climent, Batiste Andreu
Guillem Sánchez, María Salud
Zhang, Y.
Millet Roig, José
Mazgalev, T. N.
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UPV Unit:
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Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica
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Issued date:
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Abstract:
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[EN] Dual atrioventricular (AV) nodal pathway physiology is described as two
different wave fronts that propagate from the atria to the His bundle:
one with a longer effective refractory period [fast pathway (FP)] and
a ...[+]
[EN] Dual atrioventricular (AV) nodal pathway physiology is described as two
different wave fronts that propagate from the atria to the His bundle:
one with a longer effective refractory period [fast pathway (FP)] and
a second with a shorter effective refractory period [slow pathway
(SP)]. By using His electrogram alternance, we have developed a
mathematical model of AV conduction that incorporates dual AV
nodal pathway physiology. Experiments were performed on ¿ve
rabbit atrial-AV nodal preparations to develop and test the presented
model. His electrogram alternances from the inferior margin of the
His bundle were used to identify fast and slow wave front propagations. The ability to predict AV conduction time and the interaction
between FP and SP wave fronts have been analyzed during regular
and irregular atrial rhythms (e.g., atrial ¿brillation). In addition, the
role of dual AV nodal pathway wave fronts in the generation of
Wenckebach periodicities has been illustrated. Finally, AV node
ablative modi¿cations have been evaluated. The model accurately
reproduced interactions between FP and SP during regular and irregular atrial pacing protocols. In all experiments, speci¿city and sensitivity higher than 85% were obtained in the prediction of the pathway
responsible for conduction. It has been shown that, during atrial
¿brillation, the SP ablation signi¿cantly increased the mean HH
interval (204 39 vs. 274 50 ms, P 0.05), whereas FP ablation
did not produce signi¿cant slowing of ventricular rate. The presented
mathematical model can help in understanding some of the intriguing
AV node mechanisms and should be considered as a step forward in
the studies of AV nodal conduction.
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Subjects:
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Atrial arrhythmias
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Wenckebach
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Atrial fibrillation
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Ventricular rate control
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Paroxysmal supraventicular tachycardia
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Radiofrequency catheter modification
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Copyrigths:
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Cerrado |
Source:
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AJP - Heart and Circulatory Physiology. (issn:
0363-6135
)
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DOI:
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10.1152/ajpheart.01175.2010
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Publisher:
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American Physiological Society
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Publisher version:
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http://ajpheart.physiology.org/content/300/4/H1393.full.pdf+html
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Project ID:
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info:eu-repo/grantAgreement/MICINN//TEC2009-13939/ES/Desarrollo De Tecnicas Avanzadas De Analisis Y Caracterizacion De Mapas De Propagacion Para La Ayuda Al Diagnostico Electrocardiografico./
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Thanks:
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This work was supported by the Spanish Ministry of Education and Science under TEC2009-13939 and by the Universitat Politecnica de Valencia through its research initiative program. In addition, partial support was provided ...[+]
This work was supported by the Spanish Ministry of Education and Science under TEC2009-13939 and by the Universitat Politecnica de Valencia through its research initiative program. In addition, partial support was provided by a grant from the State of Ohio to the Cleveland Clinic Atrial Fibrillation Innovation Center, a Wright Center of Innovation.
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Type:
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Artículo
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