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Genetic polymorphisms located in genes related to immune and inflammatory processes are associated with end-stage renal disease: a preliminary study

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Genetic polymorphisms located in genes related to immune and inflammatory processes are associated with end-stage renal disease: a preliminary study

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dc.contributor.author Jimenez-Sousa, Mª Angeles es_ES
dc.contributor.author López, Elisabeth es_ES
dc.contributor.author Fernandez-Rodriguez, Amanda es_ES
dc.contributor.author Tamayo, Eduardo es_ES
dc.contributor.author Fernández-Navarro, Pablo es_ES
dc.contributor.author Segura Roda, Laura es_ES
dc.contributor.author Heredia, Maria es_ES
dc.contributor.author Gómez-Herreras, José I. es_ES
dc.contributor.author Bustamante, Jesus es_ES
dc.contributor.author García Gómez, Juan Miguel es_ES
dc.contributor.author Bermejo-Martin, Jesus F. es_ES
dc.contributor.author Resino, Salvador
dc.date.accessioned 2013-09-04T09:39:12Z
dc.date.available 2013-09-04T09:39:12Z
dc.date.issued 2012
dc.identifier.issn 1471-2350
dc.identifier.uri http://hdl.handle.net/10251/31748
dc.description.abstract Background Chronic kidney disease progression has been linked to pro-inflammatory cytokines and markers of inflammation. These markers are also elevated in end-stage renal disease (ESRD), which constitutes a serious public health problem. Objective To investigate whether single nucleotide polymorphisms (SNPs) located in genes related to immune and inflammatory processes, could be associated with ESRD development. Design and methods A retrospective case-control study was carried out on 276 patients with ESRD and 288 control subjects. Forty-eight SNPs were genotyped via SNPlex platform. Logistic regression was used to assess the relationship between each sigle polymorphism and the development of ESRD. Results Four polymorphisms showed association with ESRD: rs1801275 in the interleukin 4 receptor (IL4R) gene (OR: 0.66 (95%CI=0.46-0.95); p=0.025; overdominant model), rs4586 in chemokine (C-C motif) ligand 2 (CCL2) gene (OR: 0.70 (95%CI=0.54-0.90); p=0.005; additive model), rs301640 located in an intergenic binding site for signal transducer and activator of transcription 4 (STAT4) (OR: 1.82 (95%CI=1.17-2.83); p=0.006; additive model) and rs7830 in the nitric oxide synthase 3 (NOS3) gene (OR: 1.31 (95%CI=1.01-1.71); p=0.043; additive model). After adjusting for multiple testing, results lost significance. Conclusion Our preliminary data suggest that four genetic polymorphisms located in genes related to inflammation and immune processes could help to predict the risk of developing ESRD. es_ES
dc.description.sponsorship This work was supported by grants from Instituto de Salud Carlos III (Ref: PI08/0738 and PI11/00245) to SR and Junta de Castilla y Leon (Ref: GRS 234/A/08) to ET. MAJS is supported by a grant from Instituto de Salud Carlos III (CM10/00105). en_EN
dc.language Inglés es_ES
dc.publisher BioMed Central es_ES
dc.relation.ispartof BMC Medical Genetics es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject ESRD es_ES
dc.subject Kidney es_ES
dc.subject Genetic polymorphism es_ES
dc.subject Inflammation es_ES
dc.subject Immunity es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title Genetic polymorphisms located in genes related to immune and inflammatory processes are associated with end-stage renal disease: a preliminary study es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1186/1471-2350-13-58
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//08%2F0738/ES/HEPATITIS C EN PACIENTES COINFECTADOS POR VIH%2FVHC: INFLUENCIA DE LOS POLIMORFISMOS GENETICOS DE UN SOLO NUCLEOTIDO (SNPS)/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//PI11%2F00245/ES/Erradicación del VHC en pacientes coinfectados por VIH%2FVHC: efectos sobre la inflamación, el daño endotelial, la activación inmune y la aterosclerosis preclínica/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//CM10%2F00105/ES/CM10%2F00105/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Junta de Castilla y León//234%2FA%2F08/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario de Aplicaciones de las Tecnologías de la Información - Institut Universitari d'Aplicacions de les Tecnologies de la Informació es_ES
dc.description.bibliographicCitation Jimenez-Sousa, MA.; López, E.; Fernandez-Rodriguez, A.; Tamayo, E.; Fernández-Navarro, P.; Segura Roda, L.; Heredia, M.... (2012). Genetic polymorphisms located in genes related to immune and inflammatory processes are associated with end-stage renal disease: a preliminary study. BMC Medical Genetics. 13(58):1-6. https://doi.org/10.1186/1471-2350-13-58 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1186/1471-2350-13-58 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 6 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 13 es_ES
dc.description.issue 58 es_ES
dc.relation.senia 224412
dc.identifier.pmid 22817530 en_EN
dc.identifier.pmcid PMC3412707 en_EN
dc.contributor.funder Junta de Castilla y León es_ES
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