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Assessment of parameters influencing fiber characteristics of electrospun Poly(ethyl methacrylate) scaffolds

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Assessment of parameters influencing fiber characteristics of electrospun Poly(ethyl methacrylate) scaffolds

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dc.contributor.author Gómez-Tejedor, José Antonio es_ES
dc.contributor.author Van Overberghe, Niek es_ES
dc.contributor.author Rico Tortosa, Patricia María es_ES
dc.contributor.author Gómez Ribelles, José Luís es_ES
dc.date.accessioned 2013-09-11T06:23:57Z
dc.date.issued 2011
dc.identifier.issn 0014-3057
dc.identifier.uri http://hdl.handle.net/10251/31953
dc.description.abstract This work evaluates the influence of electrospinning process parameters on the mean diameter and standard deviation of fiber diameters in electrospun poly(ethyl methacrylate) (PEMA). Processing conditions were selected using Taguchi's statistical method. Oriented and unoriented electrospun mats with good mechanical properties were produced and demonstrated with tensile stress-strain diagrams. Differential scanning calorimetry (DSC) experiments showed that the polymer chains were forced into non-equilibrium conformations due to electrospinning. Enthalpic recovery during a heating scan is shown by an endothermic peak in the initial DSC heating scan that disappears in subsequent heating scans. An increase in the glass transition temperature with respect to PEMA films shows that the polymer is not equilibrated by heating above glass transition. Cell attachment was tested with MC3T3-E1 pre-osteoblastic cells cultured for short time periods on the electrospun mats. It is shown that the cells present less extended morphology with more diffuse perimetral focal adhesions than cells cultured on flat substrates. A tendency of cells to align in the direction of the substrate fibers in oriented electrospun membranes was also found. © 2010 Elsevier Ltd. All rights reserved. es_ES
dc.description.sponsorship The language revision of this paper was funded by the Universidad Politecnica de Valencia, Spain. en_EN
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation Spanish Ministry of Science [MAT2007-66759-C03-01] es_ES
dc.relation European Regional Development Fund es_ES
dc.relation Generalitat Valenciana [ACOMP/2009/112, GVPRE/2008/160] es_ES
dc.relation Universidad Politecnica de Valencia [2911-2008] es_ES
dc.relation regional government of Valencia es_ES
dc.relation Centro de Investigacion Principe Felipe es_ES
dc.relation Instituto de Salud Carlos III (Spanish Ministry of Science and Innovation) es_ES
dc.relation Universidad Politecnica de Valencia, Spain es_ES
dc.relation.ispartof EUROPEAN POLYMER JOURNAL es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Cell growth es_ES
dc.subject Electrospinning es_ES
dc.subject PEMA es_ES
dc.subject Scaffold es_ES
dc.subject Cell attachments es_ES
dc.subject Electrospinning process es_ES
dc.subject Electrospun membranes es_ES
dc.subject Electrospuns es_ES
dc.subject Endothermic peaks es_ES
dc.subject Enthalpic recovery es_ES
dc.subject Fiber characteristics es_ES
dc.subject Flat substrates es_ES
dc.subject Focal adhesions es_ES
dc.subject Glass transition temperature es_ES
dc.subject MC3T3-E1 es_ES
dc.subject Mean diameter es_ES
dc.subject Non equilibrium es_ES
dc.subject Osteoblastic cells es_ES
dc.subject Poly(ethyl methacrylate) es_ES
dc.subject Polymer chains es_ES
dc.subject Processing condition es_ES
dc.subject Standard deviation of fiber diameter es_ES
dc.subject Stress-strain diagram es_ES
dc.subject Taguchi es_ES
dc.subject Time-periods es_ES
dc.subject Biomechanics es_ES
dc.subject Differential scanning calorimetry es_ES
dc.subject Glass es_ES
dc.subject Growth kinetics es_ES
dc.subject Heating es_ES
dc.subject Mechanical properties es_ES
dc.subject Polymer films es_ES
dc.subject Scaffolds es_ES
dc.subject Strain es_ES
dc.subject Stress-strain curves es_ES
dc.subject Stresses es_ES
dc.subject Substrates es_ES
dc.subject Glass transition es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Assessment of parameters influencing fiber characteristics of electrospun Poly(ethyl methacrylate) scaffolds es_ES
dc.type Artículo es_ES
dc.embargo.lift 10000-01-01
dc.embargo.terms forever es_ES
dc.identifier.doi 10.1016/j.eurpolymj.2010.10.034
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.description.bibliographicCitation Gómez-Tejedor, JA.; Van Overberghe, N.; Rico Tortosa, PM.; Gómez Ribelles, JL. (2011). Assessment of parameters influencing fiber characteristics of electrospun Poly(ethyl methacrylate) scaffolds. EUROPEAN POLYMER JOURNAL. 47(2):119-129. doi:10.1016/j.eurpolymj.2010.10.034 es_ES
dc.description.accrualMethod Senia es_ES
dc.relation.publisherversion http://dx.doi.org/10.1016/j.eurpolymj.2010.10.034 es_ES
dc.description.upvformatpinicio 119 es_ES
dc.description.upvformatpfin 129 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 47 es_ES
dc.description.issue 2 es_ES
dc.relation.senia 39279


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