Marín Melchor, M.; Lhiaubet, VL.; Miranda Alonso, MÁ. (2012). Enhanced photochemical [6pi] electrocyclization within the lipophilic protein binding site. Organic letters. 14(7):1788-1791. https://doi.org/10.1021/ol3003805
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/33011
Title:
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Enhanced photochemical [6pi] electrocyclization within the lipophilic protein binding site
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Author:
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Marín Melchor, Mireia
Lhiaubet, Virginie Lyria
Miranda Alonso, Miguel Ángel
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UPV Unit:
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Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química
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Issued date:
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Abstract:
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Photocyclization of N-methyldiphenylamine to N-methylcarbazole is achieved within the microenvironment provided by site I of serum albumins.
Quantum yield determinations, combined with transient absorption spectroscopic ...[+]
Photocyclization of N-methyldiphenylamine to N-methylcarbazole is achieved within the microenvironment provided by site I of serum albumins.
Quantum yield determinations, combined with transient absorption spectroscopic detection of the dihydrocarbazole intermediate, demonstrate that protein encapsulation provides a subtle control of the kinetic parameters, leading to optimized efficiencies.
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Subjects:
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Human-serum-albumin
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N methyldiphenylamine
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Drug
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Photoconversion
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State
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Stereodifferentiation
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Photocyclization
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Methylcarbazole
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Diphenylamines
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Switches
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Copyrigths:
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Cerrado |
Source:
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Organic letters. (issn:
1523-7060
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DOI:
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10.1021/ol3003805
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Publisher:
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American Chemical Society
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Publisher version:
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http://pubs.acs.org/doi/pdf/10.1021/ol3003805
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Project ID:
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info:eu-repo/grantAgreement/MICINN//CTQ2009-13699/ES/CTQ2009-13699/
info:eu-repo/grantAgreement/GVA//PROMETEO08%2F2008%2F090/ES/Especies fotoactivas como sondas para proteínas/
info:eu-repo/grantAgreement/MEC//RYC-2007-00476/ES/RYC-2007-00476/
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Thanks:
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This work was funded by the Spanish Government (Project CTQ2009-13699, Ramon y Cajal contract RyC-2007-00476 to V.L.-V. and JAE-predoc contract to M.M.) and the Generalitat Valenciana (Prometeo/2008/090).
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Type:
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Artículo
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