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Gold nanoparticles supported on nanoparticulate ceria as a powerful agent against intracellular oxidative stress

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Gold nanoparticles supported on nanoparticulate ceria as a powerful agent against intracellular oxidative stress

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dc.contributor.author Menchón, Cristina es_ES
dc.contributor.author Martín González, Roberto es_ES
dc.contributor.author Apostolova, Nadezda es_ES
dc.contributor.author Victor, V. M. es_ES
dc.contributor.author Alvaro Rodríguez, Maria Mercedes es_ES
dc.contributor.author Herance Camacho, Jose Raul es_ES
dc.contributor.author García Gómez, Hermenegildo
dc.date.accessioned 2013-10-30T11:07:22Z
dc.date.issued 2012-06-25
dc.identifier.issn 1613-6810
dc.identifier.uri http://hdl.handle.net/10251/33132
dc.description.abstract Ceria-supported gold nanoparticles are prepared exhibiting peroxidase activity and acting as radical traps. Au/CeO2 shows a remarkable biocompatibility as demonstrated by measuring cellular viability, proliferation, and lack of apoptosis for two human cell lines (Hep3B and HeLa). The antioxidant activity of Au/CeO2 against reactive oxygen species (ROS) is demonstrated by studying the cellular behavior of Hep3B and HeLa in a model of cellular oxidative stress. It is determined that Au/CeO2 exhibits higher antioxidant activity than glutathione, the main cytosolic antioxidant compound, and its CeO2 carrier. Overall the result presented here shows the potential of implementing well-established nanoparticulated gold catalysts with remarkable biocompatibility in cellular biology. es_ES
dc.description.sponsorship Financial support by the Spanish ministry of Science is (CTQ2006-06785 and CTQ2007-67805-AR07, PI10/1195, AP192/11) is gratefully acknowledged. RM also thanks Spanish Ministry of Education for a postgraduate scholarship. VMV is recipient of Regional Ministry of Health of the Valencian Community and Carlos III Health Institute contract (ACOMP/2012/045 and CES10/030). NA is a recipient of VALi+D contract (APOSTD/2011/049). en_EN
dc.format.extent 9 es_ES
dc.language Inglés es_ES
dc.publisher Wiley-VCH Verlag es_ES
dc.relation MICINN/CTQ2007-67805-AR07
dc.relation MICINN/CTQ2006-06785
dc.relation MICINN/PI10/1195
dc.relation MICINN/AP192/11
dc.relation ISCIII/ACOMP/2012/045
dc.relation ISCIII/CES10/030
dc.relation GVA/APOSTD/2011/049
dc.relation.ispartof Small es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Gold nanoparticles es_ES
dc.subject Intracellular oxidative stress es_ES
dc.subject Peroxidase activity es_ES
dc.subject Ceria es_ES
dc.subject Nanomedicine es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.title Gold nanoparticles supported on nanoparticulate ceria as a powerful agent against intracellular oxidative stress es_ES
dc.type Artículo es_ES
dc.embargo.lift 10000-01-01
dc.embargo.terms forever es_ES
dc.identifier.doi 10.1002/smll.201102255
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Menchón, C.; Martín González, R.; Apostolova, N.; Victor, VM.; Alvaro Rodríguez, MM.; Herance Camacho, JR.; García Gómez, H. (2012). Gold nanoparticles supported on nanoparticulate ceria as a powerful agent against intracellular oxidative stress. Small. 8(12):1895-1903. https://doi.org/10.1002/smll.201102255 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/ 10.1002/smll.201102255 es_ES
dc.description.upvformatpinicio 1895 es_ES
dc.description.upvformatpfin 1903 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 8 es_ES
dc.description.issue 12 es_ES
dc.relation.senia 242180
dc.contributor.funder Ministerio de Ciencia e Innovación
dc.contributor.funder Ministerio de Educación, Cultura y Deporte
dc.contributor.funder Generalitat Valenciana
dc.contributor.funder Instituto de Salud Carlos III


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