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Design, Synthesis, and Biological Evaluation of Novel Fluorinated Ethanolamines

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Design, Synthesis, and Biological Evaluation of Novel Fluorinated Ethanolamines

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Fustero, S.; Cuñat, AC.; Flores, S.; Baez, C.; Oliver, J.; Cynamon, M.; Gütschow, M.... (2011). Design, Synthesis, and Biological Evaluation of Novel Fluorinated Ethanolamines. Chemistry - A European Journal. 17:14772-14784. doi:10.1002/chem.201102078

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Title: Design, Synthesis, and Biological Evaluation of Novel Fluorinated Ethanolamines
Author: Fustero, Santos Cuñat, Ana C. Flores, Sonia Baez, Claribel Oliver, Judit Cynamon, Michael Gütschow, Michael Mertens, Matthias D. Delgado, Oscar Tresadem, Gary Trabanco, Andrés A.
Issued date:
Abstract:
The preparation of novel fluorinated allylamines and their use as key fragments for the stereoselective synthesis of hydroxyethyl secondary amine (HEA)-type peptidomimetics is described. Our strategy employs chiral sulfinyl ...[+]
Subjects: Antimicrobials , BACE1 , Ethanolamines , Fluorine , Peptidomimetics
Copyrigths: Cerrado
Source:
Chemistry - A European Journal. (issn: 0947-6539 )
DOI: 10.1002/chem.201102078
Publisher:
Wiley-VCH Verlag
Publisher version: http://dx.doi.org/10.1002/chem.201102078
Type: Artículo

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