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Reactivity of Nucleosides with a Hydroxyl Radical in Non-aqueous Medium

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Reactivity of Nucleosides with a Hydroxyl Radical in Non-aqueous Medium

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dc.contributor.author Rodríguez Muñiz, Gemma María es_ES
dc.contributor.author Marín García, Mª Luisa es_ES
dc.contributor.author Lhiaubet, Virginie Lyria es_ES
dc.contributor.author Miranda Alonso, Miguel Ángel es_ES
dc.date.accessioned 2013-11-15T08:38:15Z
dc.date.issued 2012-06-25
dc.identifier.issn 0947-6539
dc.identifier.uri http://hdl.handle.net/10251/33614
dc.description.abstract DNA damage: The reactivity of HO. with silylated 2¿-deoxyribonucleosides was investigated in acetonitrile by means of a time-resolved technique. The obtained rate constants were in general slightly lower than those reported for the natural nucleosides in water. Analysis of the reaction mixture by UPLC-MS revealed that HO. attack occurred at the nucleobase (see scheme). es_ES
dc.description.sponsorship The Spanish Government (CTQ2009-13699 and Ramon y Cajal contract (RyC-2007-00476) to V. L. V) is gratefully acknowledged. en_EN
dc.format.extent 4 es_ES
dc.language Inglés es_ES
dc.publisher Wiley-VCH Verlag es_ES
dc.relation MICINN/CTQ2009-13699
dc.relation MICINN/RyC-2007-00476
dc.relation.ispartof Chemistry - A European Journal es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject DNA damage es_ES
dc.subject Laser flash photolysis es_ES
dc.subject Nucleobases es_ES
dc.subject Photochemistry es_ES
dc.subject Time-resolved spectroscopy es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.title Reactivity of Nucleosides with a Hydroxyl Radical in Non-aqueous Medium es_ES
dc.type Artículo es_ES
dc.embargo.lift 10000-01-01
dc.embargo.terms forever es_ES
dc.identifier.doi 10.1002/chem.201201090
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Tecnología Química - Institut de Tecnologia Química es_ES
dc.description.bibliographicCitation Rodríguez Muñiz, GM.; Marín García, ML.; Lhiaubet, VL.; Miranda Alonso, MÁ. (2012). Reactivity of Nucleosides with a Hydroxyl Radical in Non-aqueous Medium. Chemistry - A European Journal. 18:8024-8027. doi:10.1002/chem.201201090 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1002/chem.201201090 es_ES
dc.description.upvformatpinicio 8024 es_ES
dc.description.upvformatpfin 8027 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 18 es_ES
dc.relation.senia 237421
dc.contributor.funder Ministerio de Ciencia e Innovación


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