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dc.contributor.author | Bernardos Bau, Andrea | es_ES |
dc.contributor.author | Mondragón Martínez, Laura | es_ES |
dc.contributor.author | Javakhishvili, Irakli | es_ES |
dc.contributor.author | Mas Font, Nuria | es_ES |
dc.contributor.author | De la Torre Paredes, Cristina | es_ES |
dc.contributor.author | Martínez Mañez, Ramón | es_ES |
dc.contributor.author | Sancenón Galarza, Félix | es_ES |
dc.contributor.author | Barat Baviera, José Manuel | es_ES |
dc.contributor.author | Hvilsted, Soren | es_ES |
dc.contributor.author | Orzaez, Mar | es_ES |
dc.contributor.author | Pérez Payá, Enrique | es_ES |
dc.contributor.author | Amorós, Pedro | es_ES |
dc.date.accessioned | 2013-11-19T13:19:35Z | |
dc.date.issued | 2012-10-08 | |
dc.identifier.issn | 0947-6539 | |
dc.identifier.uri | http://hdl.handle.net/10251/33745 | |
dc.description.abstract | The synthesis and characterisation of new capped silica mesoporous nanoparticles for on-command delivery applications is reported. Functional capped hybrid systems consist of MCM-41 nanoparticles functionalised on the external surface with polyesters bearing azobenzene derivatives and rhodamine¿B inside the mesopores. Two solid materials, Rh-PAzo8-S and Rh-PAzo6-S, containing two closely related polymers, PAzo8 and PAzo6, in the pore outlets have been prepared. Materials Rh-PAzo8-S and Rh-PAzo6-S showed an almost zero release in water due to steric hindrance imposed by the presence of anchored bulky polyesters, whereas a large delivery of the cargo was observed in the presence of an esterase enzyme due to the progressive hydrolysis of polyester chains. Moreover, nanoparticles Rh-PAzo8-S and Rh-PAzo6-S were used to study the controlled release of the dye in intracellular media. Nanoparticles were not toxic for HeLa cells and endocytosis-mediated cell internalisation was confirmed by confocal microscopy. Furthermore, the possible use of capped materials as a drug-delivery system was demonstrated by the preparation of a new mesoporous silica nanoparticle functionalised with PAzo6 and loaded with the cytotoxic drug camptothecin (CPT-PAzo6-S). Following cell internalisation and lysosome resident enzyme-dependent gate opening, CPT-PAzo6-S induced CPT-dependent cell death in HeLa cells. | es_ES |
dc.description.sponsorship | We thank the Spanish Government (projects MAT2009-14564-C04, CTQ2007-64735-AR07 and SAF2010-15512) and the Generalitat Valencia (projects PROMETEO/2009/016 and PROMETEO/2010/005) for support. A. B. is grateful to the Universidad Politecnica de Valencia for an FPI grant. L. M. thanks the Generalitat Valenciana for the Santiago Grisolia Fellowship she received and the VALI+D postdoctoral contract. We thank the CIPF confocal microscopy service for its technical support. | en_EN |
dc.format.extent | 11 | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | Wiley-VCH Verlag | es_ES |
dc.relation.ispartof | Chemistry - A European Journal | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Azo compounds | es_ES |
dc.subject | Drug delivery | es_ES |
dc.subject | Enzymes | es_ES |
dc.subject | Mesoporous materials | es_ES |
dc.subject | Polyesters | es_ES |
dc.subject.classification | QUIMICA INORGANICA | es_ES |
dc.subject.classification | QUIMICA ORGANICA | es_ES |
dc.subject.classification | TECNOLOGIA DE ALIMENTOS | es_ES |
dc.title | Azobenzene polyesters used as gate-like scaffolds in nanoscopic hybrid systems | es_ES |
dc.type | Artículo | es_ES |
dc.embargo.lift | 10000-01-01 | |
dc.embargo.terms | forever | es_ES |
dc.identifier.doi | 10.1002/chem.201200787 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MEC//CTQ2007-64735/ES/ESTRATEGIAS PARA EL DESARROLLO DE MICROSISTEMAS ANALITICOS DE BARRIDO BASADOS EN RECEPTORES BIOMOLECULARES Y SU APLICACION A LAS CIENCIAS DE LA VIDA/ / | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/Generalitat Valenciana//PROMETEO09%2F2009%2F016/ES/Ayuda prometeo 2009 para el grupo de diseño y desarrollo de sensores/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/Generalitat Valenciana//PROMETEO%2F2010%2F005/ES/PROMETEO%2F2010%2F005/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//SAF2010-15512/ES/MECANISMOS MOLECULARES DE MODULADORES DE APOPTOSIS/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//MAT2009-14564-C04-04/ES/Nanomateriales Mesoporosos Y Particulados Para El Diseño De Sistemas Sensores, Remediacion Y Aplicaciones Relacionadas Con La Energia/ / | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//MAT2009-14564-C04-01/ES/Nanomateriales Hibridos Para El Desarrollo De "Puertas Moleculares" De Aplicacion En Procesos De Reconocimiento Y Terapeutica Y Para La Deteccion De Explosivos./ | es_ES |
dc.rights.accessRights | Cerrado | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Química - Departament de Química | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Tecnología de Alimentos - Departament de Tecnologia d'Aliments | es_ES |
dc.description.bibliographicCitation | Bernardos Bau, A.; Mondragón Martínez, L.; Javakhishvili, I.; Mas Font, N.; De La Torre Paredes, C.; Martínez Máñez, R.; Sancenón Galarza, F.... (2012). Azobenzene polyesters used as gate-like scaffolds in nanoscopic hybrid systems. Chemistry - A European Journal. 18(41):13068-13078. doi:10.1002/chem.201200787 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | http://onlinelibrary.wiley.com/doi/10.1002/chem.201200787/pdf | es_ES |
dc.description.upvformatpinicio | 13068 | es_ES |
dc.description.upvformatpfin | 13078 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 18 | es_ES |
dc.description.issue | 41 | es_ES |
dc.relation.senia | 230312 | |
dc.contributor.funder | Ministerio de Educación y Ciencia | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación | es_ES |
dc.contributor.funder | Universitat Politècnica de València | es_ES |
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