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Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentials

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Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentials

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Zemzemi, N.; Bernabeu, MO.; Saiz Rodríguez, FJ.; Cooper, J.; Pathmanathan, P.; Mirams, GR.; Pitt-Francis, J.... (2013). Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentials. British Journal of Pharmacology. 168(3):718-733. doi:10.1111/j.1476-5381.2012.02200.x

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/34675

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Title: Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentials
Author:
UPV Unit: Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica
Issued date:
Abstract:
BACKGROUND AND PURPOSE Understanding drug effects on the heart is key to safety pharmacology assessment and anti-arrhythmic therapy development. Here our goal is to demonstrate the ability of computational models to ...[+]
Subjects: ECG modelling , Computer simulation , Drug , HERG , Sodium blockers , QT prolongation , QRS widening
Copyrigths: Reserva de todos los derechos
Source:
British Journal of Pharmacology. (issn: 0007-1188 )
DOI: 10.1111/j.1476-5381.2012.02200.x
Publisher:
Wiley-Blackwell
Publisher version: http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02200.x/pdf
Project ID: info:eu-repo/grantAgreement/EC/FP7/224381/EU
Thanks:
The authors would like to thank Drs Philippe Moireau, Miguel Fernandez and Elsie Phe from INRIA Paris-Rocquencourt for their work on the anatomical models and meshes. We are also grateful to Professors Dominique Chapelle ...[+]
Type: Artículo

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