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A CANDLE for a deeper in-vivo insight

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A CANDLE for a deeper in-vivo insight

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dc.contributor.author Coupé, Pierrick es_ES
dc.contributor.author Munz, Martin es_ES
dc.contributor.author Manjón Herrera, José Vicente es_ES
dc.contributor.author Ruthazer, Edward S. es_ES
dc.contributor.author Collins, D. Louis es_ES
dc.date.accessioned 2014-03-31T06:44:54Z
dc.date.issued 2012-05
dc.identifier.issn 1361-8415
dc.identifier.uri http://hdl.handle.net/10251/36728
dc.description.abstract A new Collaborative Approach for eNhanced Denoising under Low-light Excitation (CANDLE) is introduced for the processing of 3D laser scanning multiphoton microscopy images. CANDLE is designed to be robust for low signal-to-noise ratio (SNR) conditions typically encountered when imaging deep in scattering biological specimens. Based on an optimized non-local means filter involving the comparison of filtered patches, CANDLE locally adapts the amount of smoothing in order to deal with the noise inhomogeneity inherent to laser scanning fluorescence microscopy images. An extensive validation on synthetic data, images acquired on microspheres and in vivo images is presented. These experiments show that the CANDLE filter obtained competitive results compared to a state-of-the-art method and a locally adaptive optimized non-local means filter, especially under low SNR conditions (PSNR < 8 dB). Finally, the deeper imaging capabilities enabled by the proposed filter are demonstrated on deep tissue in vivo images of neurons and fine axonal processes in the Xenopus tadpole brain. es_ES
dc.description.sponsorship We want to thank Florian Luisier for providing free plugin of his PureDenoise filter. We also want to thank Markku Makitalo for providing the code of their OVST. This study was supported by the Canadian Institutes of Health Research (CIHR, MOP-84360 to DLC and MOP-77567 to ESR) and Cda (CECR)-Gevas-OE016. MM holds a fellowship from the Deutscher Akademischer Austasch Dienst (DAAD) and a McGill Principal's Award. ESR is a tier 2 Canada Research Chair. This work has been partially supported by the Spanish Health Institute Carlos III through the RETICS Combiomed, RD07/0067/2001. This work benefited from the use of ImageJ. en_EN
dc.format.extent 16 es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Medical Image Analysis es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Image denoising es_ES
dc.subject Image enhancement es_ES
dc.subject Multiphoton imaging es_ES
dc.subject Confocal imaging es_ES
dc.subject Non-local means filter es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title A CANDLE for a deeper in-vivo insight es_ES
dc.type Artículo es_ES
dc.embargo.lift 10000-01-01
dc.embargo.terms forever es_ES
dc.identifier.doi 10.1016/j.media.2012.01.002
dc.relation.projectID info:eu-repo/grantAgreement/CIHR//MOP-84360/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/CIHR//Cda (CECR)-Gevas-OE016/CA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/CIHR//MOP-77567/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//RD07%2F0067%2F2001/ES/RED TEMÁTICA DE INVESTIGACIÓN COOPERATIVA EN BIOMEDICINA COMPUTACIONAL/ / es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.description.bibliographicCitation Coupé, P.; Munz, M.; Manjón Herrera, JV.; Ruthazer, ES.; Collins, DL. (2012). A CANDLE for a deeper in-vivo insight. Medical Image Analysis. 16(4):849-864. https://doi.org/10.1016/j.media.2012.01.002 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1016/j.media.2012.01.002 es_ES
dc.description.upvformatpinicio 849 es_ES
dc.description.upvformatpfin 864 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 16 es_ES
dc.description.issue 4 es_ES
dc.relation.senia 237119
dc.identifier.pmid 22341767 es_ES
dc.identifier.pmcid PMC3403005 es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Canadian Institutes of Health Research es_ES
dc.contributor.funder Deutscher Akademischer Austauschdienst es_ES


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