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Changing the General Factor of Personality and the c-fos Gene Expression with Methylphenidate and Self-Regulation Therapy

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Changing the General Factor of Personality and the c-fos Gene Expression with Methylphenidate and Self-Regulation Therapy

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Nombre: Joan C. Micó;SALVADOR ...
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dc.contributor.author Micó Ruiz, Juan Carlos es_ES
dc.contributor.author Amigó Borrás, Salvador es_ES
dc.contributor.author Caselles Moncho, Antonio es_ES
dc.date.accessioned 2014-04-02T12:07:14Z
dc.date.available 2014-04-02T12:07:14Z
dc.date.issued 2012
dc.identifier.issn 1138-7416
dc.identifier.uri http://hdl.handle.net/10251/36790
dc.description.abstract [EN] A deepening in the biological nature of the general factor of personality (GFP) is suggested: the activation level of the stress system is here represented by the gene expression of c-fos. The results of a single case experimental design are reported. A model of four coupled differential equations that explains the human personality dynamics as a consequence of a single stimulant drug intake has been fitted to psychological and biological experimental data. The stimulant-drug conditioning and its adaptation to the considered mathematical model is also studied for both kinds of measures. The dynamics of the cfos expression presents a similar pattern to the dynamics of the psychological measures of personality assessed by the GFP-FAS (Five-Adjective Scale of the General Factor of Personality) as a consequence of a single dose of stimulant drug (methylphenidate). The model predicts similar dynamic patterns for both psychological and biological measures. This study proves that describing mathematically the dynamics of the effects of a stimulant drug as well as the effects of a conditioning method on psychological or subjective variables and on gene expression is possible. It verifies the existence of biological mechanisms underlying the dynamics of the General Factor of Personality (GFP). es_ES
dc.description.abstract [ES] Este artículo estudia la naturaleza dinámica del Factor General de Personalidad (FGP) en respuesta a una dosis única de metilfenidato a partir de un diseño experimental de caso único con replicación. Para medir el FGP, se emplean tanto medidas psicológicas (Escala de Cinco Adjetivos del Factor General de Personalidad; ECA-FGP), como un marcador biológico (propuesto como substrato biológico del FGP) que es la concentración del gen c-fos en los linfocitos de la sangre. También se estudia el condicionamiento de los efectos subjetivo y biológico del metilfenidato con una técnica de sugestión y condicionamiento, denominada terapia de auto-regulación. Por último, se propone un modelo matemático de cuatro ecuaciones diferenciales acopladas que explican la dinámica del FGP como consecuencia de una ingestión de droga estimulante y del condicionamiento de la droga, ajustadas a los datos experimentales psicológicos y biológicos. Los resultados muestran un patrón dinámico similar para ambas medidas psicológicas y biológicas del FGP en respuesta tanto a una dosis de metilfenidato como al condicionamiento con terapia de auto-regulación.Así, se evidencia que es posible la formulación matemática de la dinámica del FGP y sus correlatos biológicos, como el gen regulador c-fos, y su condicionamiento mediante la terapia de auto-regulación. es_ES
dc.language Inglés es_ES
dc.publisher Cambridge University Press (CUP) es_ES
dc.relation.ispartof Spanish Journal of Psychology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Personality es_ES
dc.subject General factor of personality es_ES
dc.subject Self-regulation therapy es_ES
dc.subject Methylphenidate es_ES
dc.subject C-fos es_ES
dc.subject Dynamic model es_ES
dc.subject Personalidad es_ES
dc.subject Factor general de personalidad es_ES
dc.subject Terapia de auto-regulación es_ES
dc.subject Metilfenidato es_ES
dc.subject Modelo dinámico es_ES
dc.subject.classification MATEMATICA APLICADA es_ES
dc.title Changing the General Factor of Personality and the c-fos Gene Expression with Methylphenidate and Self-Regulation Therapy es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.5209/rev_SJOP.2012.v15.n2.38896
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada es_ES
dc.description.bibliographicCitation Micó Ruiz, JC.; Amigó Borrás, S.; Caselles Moncho, A. (2012). Changing the General Factor of Personality and the c-fos Gene Expression with Methylphenidate and Self-Regulation Therapy. Spanish Journal of Psychology. 15(2):850-867. doi:10.5209/rev_SJOP.2012.v15.n2.38896 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.5209/rev_SJOP.2012.v15.n2.38896 es_ES
dc.description.upvformatpinicio 850 es_ES
dc.description.upvformatpfin 867 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 15 es_ES
dc.description.issue 2 es_ES
dc.relation.senia 232395
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