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Chemical Surface Modifications development of Silicon Based Label Free Integrated Optical (IO) Biosensors: A Review

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Chemical Surface Modifications development of Silicon Based Label Free Integrated Optical (IO) Biosensors: A Review

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dc.contributor.author Bañuls Polo, Mª José es_ES
dc.contributor.author Puchades Pla, Rosa es_ES
dc.contributor.author Maquieira Catala, Ángel es_ES
dc.date.accessioned 2014-05-21T12:29:36Z
dc.date.issued 2013-01-23
dc.identifier.issn 0003-2670
dc.identifier.uri http://hdl.handle.net/10251/37663
dc.description.abstract [EN] Increasing interest has been paid to label-free biosensors in recent years. 11 Among them, refractive index (RI) optical biosensors enable high density and the chip-12 scale integration of optical components. This makes them more appealing to help 13 develop lab-on-a-chip devices. Today, many RI integrated optical (IO) devices are made 14 using silicon-based materials. A key issue in their development is the 15 biofunctionalization of sensing surfaces because they provide a specific, sensitive 16 response to the analyte of interest. This review critically discusses the 17 biofunctionalization procedures, assay formats and characterization techniques 18 employed in setting up IO biosensors. In addition, it provides the most relevant results 19 obtained from using these devices for real sample biosensing. Finally, an overview of 20 the most promising future developments in the fields of chemical surface modification 21 and capture agent attachment for IO biosensors follows. es_ES
dc.description.sponsorship This research has been supported by the Spanish Ministry of Science and Innovation through project CTQ2010-15943/BQU and by the Regional Valencian Government, through GVA/PROMETEO 2010/08. The authors thank Dr. Miguel Holgado, from the Universidad Politecnica de Madrid, for his helpful discussion about the classification of RI optical sensors.
dc.language Inglés es_ES
dc.publisher Elsevier Masson es_ES
dc.relation MICINN/CTQ2010-15943/BQU es_ES
dc.relation GV/PROMETEO 2010/08 es_ES
dc.relation.ispartof Analytica Chimica Acta es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.title Chemical Surface Modifications development of Silicon Based Label Free Integrated Optical (IO) Biosensors: A Review es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.aca.2013.01.025
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Bañuls Polo, MJ.; Puchades Pla, R.; Maquieira Catala, A. (2013). Chemical Surface Modifications development of Silicon Based Label Free Integrated Optical (IO) Biosensors: A Review. Analytica Chimica Acta. 777:1-16. doi:10.1016/j.aca.2013.01.025 es_ES
dc.description.accrualMethod Senia es_ES
dc.relation.publisherversion http://dx.doi.org/10.1016/j.aca.2013.01.025 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 16 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 777 es_ES
dc.relation.senia 251917
dc.identifier.pmid 23622959
dc.contributor.funder Ministerio de Ciencia e Innovación
dc.contributor.funder Generalitat Valenciana


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