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dc.contributor.author | Santamaría Navarro, Cristina | es_ES |
dc.contributor.author | García Mora, María Belén | es_ES |
dc.contributor.author | Rubio Navarro, Gregorio | es_ES |
dc.contributor.author | Lujan Marco, Saturnino | es_ES |
dc.date.accessioned | 2014-05-27T10:47:38Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 0895-7177 | |
dc.identifier.uri | http://hdl.handle.net/10251/37787 | |
dc.description.abstract | Multiple sequential recurrences are one of the most important characteristics of superficial transitional cell carcinoma of the bladder, more than 50% of the patients will have recurrences (reappearance of a new superficial tumor). When in the same subject recurrent events are considered and these observed events are clustered into groups, independence between the clustered survival times cannot be assumed. A natural way to model the dependence of clustered event times is through the introduction of a cluster-specific random effect: the frailty term. On the other hand, between 10% and 30% of patients diagnosed with bladder carcinoma will present a muscle invasive progression, so the observation process of recurrences could be interrupted by a major failure event (progression). In this regard, a joint modelling of the two processes could make the study of a joint evolution over time possible, giving unbiased and efficient parameters. We jointly analyze recurrences and progression processes by means of the joint frailty model. | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.ispartof | Mathematical and Computer Modelling | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Joint frailty model | es_ES |
dc.subject | Survival analysis | es_ES |
dc.subject | Event dependence | es_ES |
dc.subject | Bladder carcinoma | es_ES |
dc.subject.classification | MATEMATICA APLICADA | es_ES |
dc.title | An analysis of recurrence-progression process in bladder carcinoma by means of joint frailty models | es_ES |
dc.type | Artículo | es_ES |
dc.embargo.lift | 10000-01-01 | |
dc.embargo.terms | forever | es_ES |
dc.identifier.doi | 10.1016/j.mcm.2010.11.004 | |
dc.rights.accessRights | Cerrado | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto Universitario de Matemática Multidisciplinar - Institut Universitari de Matemàtica Multidisciplinària | es_ES |
dc.description.bibliographicCitation | Santamaría Navarro, C.; García Mora, MB.; Rubio Navarro, G.; Lujan Marco, S. (2011). An analysis of recurrence-progression process in bladder carcinoma by means of joint frailty models. Mathematical and Computer Modelling. 54:1946-1950. doi:10.1016/j.mcm.2010.11.004 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.mcm.2010.11.004 | es_ES |
dc.description.upvformatpinicio | 1946 | es_ES |
dc.description.upvformatpfin | 1950 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 54 | es_ES |
dc.relation.senia | 217397 |