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A Voxel-based analysis of FDG-PET in traumatic brain injury: regional metabolism and relationship between the thalamus and cortical areas

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A Voxel-based analysis of FDG-PET in traumatic brain injury: regional metabolism and relationship between the thalamus and cortical areas

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dc.contributor.author García Panach, Javier es_ES
dc.contributor.author Lull Noguera, Nuria es_ES
dc.contributor.author Lull Noguera, Juan José es_ES
dc.contributor.author Ferri Domínguez, Joan es_ES
dc.contributor.author Martínez, Carlos es_ES
dc.contributor.author Sopena, Pablo es_ES
dc.contributor.author Robles Viejo, Montserrat es_ES
dc.contributor.author Chirivella Garrido, Javier es_ES
dc.contributor.author Noé Sebastián, Enrique es_ES
dc.date.accessioned 2014-06-19T10:43:44Z
dc.date.issued 2011-09
dc.identifier.issn 0897-7151
dc.identifier.uri http://hdl.handle.net/10251/38236
dc.description.abstract [EN] The objective was to study the correlations and the differences in glucose metabolism between the thalamus and cortical structures in a sample of severe traumatic brain injury (TBI) patients with different neurological outcomes. We studied 49 patients who had suffered a severe TBI and 10 healthy control subjects using 18Ffluorodeoxyglucose positron emission tomography (18F-FDG-PET). The patients were divided into three groups: a vegetative or minimally-conscious state (MCS&VS) group (n = 17), which included patients who were in a vegetative or a minimally conscious state; an In-post-traumatic amnesia (In-PTA) group (n = 12), which included patients in PTA; and an Out-PTA group (n = 20), which included patients who had recovered from PTA. SPM5 software was used to determine the metabolic differences between the groups. FDG-PET images were normalized and four regions of interest were generated around the thalamus, precuneus, and the frontal and temporal lobes. The groups were parameterized using Student's t-test. Principal component analysis was used to obtain an intensity-estimated-value per subject to correlate the function between the structures. Differences in glucose metabolism in all structures were related to the neurological outcome, and the most severe patients showed the most severe hypometabolism. We also found a significant correlation between the cortico-thalamocortical metabolism in all groups. Voxel-based analysis suggests a functional correlation between these four areas, and decreased metabolism was associated with less favorable outcomes. Higher levels of activation of the cortico-cortical connections appear to be related to better neurological condition. Differences in the thalamocortical correlations between patients and controls may be related to traumatic dysfunction due to focal or diffuse lesions. es_ES
dc.description.sponsorship A preliminary version of the manuscript presented here has obtained the 2nd award of IV Convocatoria de los Premios de Investigacio´n en Medicina del Colegio de Me´dicos de Valladolid (IV edition of the Medical Research Award of the Offi- cial College of Physicians of Valladolid).
dc.format.extent 11 es_ES
dc.language Inglés es_ES
dc.publisher Mary Ann Liebert es_ES
dc.relation Official College of Physicians of Valladolid es_ES
dc.relation.ispartof Journal of Neurotrauma es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Cerebral metabolism es_ES
dc.subject Consciousness es_ES
dc.subject Functional imaging es_ES
dc.subject Head injury es_ES
dc.subject Image analysis es_ES
dc.subject Positron emission tomography es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title A Voxel-based analysis of FDG-PET in traumatic brain injury: regional metabolism and relationship between the thalamus and cortical areas es_ES
dc.type Artículo es_ES
dc.embargo.lift 10000-01-01
dc.embargo.terms forever es_ES
dc.identifier.doi 10.1089/neu.2011.1851
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario de Aplicaciones de las Tecnologías de la Información - Institut Universitari d'Aplicacions de les Tecnologies de la Informació es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.description.bibliographicCitation Garcia Panach, J.; Lull Noguera, N.; Lull Noguera, JJ.; Ferri Domínguez, J.; Martínez, C.; Sopena, P.; Robles Viejo, M.... (2011). A Voxel-based analysis of FDG-PET in traumatic brain injury: regional metabolism and relationship between the thalamus and cortical areas. Journal of Neurotrauma. 28(9):1707-1717. doi:10.1089/neu.2011.1851 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://doi.org/10.1089/neu.2011.1851 es_ES
dc.description.upvformatpinicio 1707 es_ES
dc.description.upvformatpfin 1717 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 28 es_ES
dc.description.issue 9 es_ES
dc.relation.senia 222535


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