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Dansyl labeling to modulate the relative affinity of bile acids for the binding sites of human serum albumin

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Dansyl labeling to modulate the relative affinity of bile acids for the binding sites of human serum albumin

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Rohacova, J.; Sastre Navarro, GI.; Marín García, ML.; Miranda Alonso, MÁ. (2011). Dansyl labeling to modulate the relative affinity of bile acids for the binding sites of human serum albumin. Journal of Physical Chemistry B. 115(35):10518-10524. doi:10.1021/jp201788d

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/38243

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Title: Dansyl labeling to modulate the relative affinity of bile acids for the binding sites of human serum albumin
Author:
UPV Unit: Universitat Politècnica de València. Departamento de Química - Departament de Química
Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química
Issued date:
Abstract:
[EN] Binding of natural bile acids to human serum albumin (HSA) is an important step in enterohepatic circulation and provides a measure of liver function. In this article, we report on the use of four dansyl (Dns) derivatives ...[+]
Subjects: Bile acid , Binding behaviors , Binding constant , Bulk solutions , Cholic acids , Donor-acceptor distance , Human serum albumins , Lithocholic acids , Microenvironments , Regioisomers , Time-resolved fluorescence , Binding energy , Body fluids , Drug products , Energy transfer , Fluorescence , Internet protocols , Binding sites , 1 myristoyl 2 (12 ((5 dimethylamino 1 naphthalenesulfonyl)amino)dodecanoyl) sn glycero 3 phosphocholine , 1-myristoyl-2-(12-((5-dimethylamino-1-naphthalenesulfonyl)amino)dodecanoyl)-sn-glycero-3-phosphocholine , Cholic acid derivative , Phosphatidylcholine , Serum albumin , Affinity labeling , Article , Binding site , Chemistry , Human , Spectrofluorometry , Affinity Labels , Humans , Phosphatidylcholines , Spectrometry
Copyrigths: Cerrado
Source:
Journal of Physical Chemistry B. (issn: 1520-6106 )
DOI: 10.1021/jp201788d
Publisher:
American Chemical Society
Publisher version: http://dx.doi.org/10.1021/jp201788d
Thanks:
Financial support from the CSIC (Fellowship I3P-2005), the Spanish Government (CTQ2009-13699, RIRAAF RETICS), and the Generalitat Valenciana (Prometeo Program) is gratefully acknowledged. Dedicated to Prof. J. V. Castell ...[+]
Type: Artículo

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