Gómez Mendoza, M.; Nuin Plá, NE.; Andreu Ros, MI.; Marín García, ML.; Miranda Alonso, MÁ. (2012). Photophysical probes to assess the potential of cholic acid aggregates as drug carriers. Journal of Physical Chemistry B. 116(34):10213-10218. https://doi.org/10.1021/jp304708y
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/38341
Title:
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Photophysical probes to assess the potential of cholic acid aggregates as drug carriers
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Author:
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Gómez Mendoza, Miguel
Nuin Plá, Neus Edurne
Andreu Ros, María Inmaculada
Marín García, Mª Luisa
Miranda Alonso, Miguel Ángel
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UPV Unit:
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Universitat Politècnica de València. Departamento de Química - Departament de Química
Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química
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Issued date:
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Abstract:
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The two enantiomers of the nonsteroidal antiinflammatory drug naproxen and of its methyl ester have been selected as representative probes with markedly different hydrophobicity to assess the potential of cholic acid ...[+]
The two enantiomers of the nonsteroidal antiinflammatory drug naproxen and of its methyl ester have been selected as representative probes with markedly different hydrophobicity to assess the potential of cholic acid aggregates as drug carriers by means of photophysical techniques. The different distribution of the probes between bulk solution and aggregates has been assessed by quenching of their singlet and triplet excited states by iodide and nitrite anions, respectively. This straightforward photophysical methodology can, in principle, be extended to a variety of drugs containing a photoactive chromophore. © 2012 American Chemical Society.
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Subjects:
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BILE-SALT MICELLES
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BETA-CYCLODEXTRIN
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NAPROXEN
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SYSTEMS
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DERIVATIVES
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DYNAMICS
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Copyrigths:
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Cerrado |
Source:
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Journal of Physical Chemistry B. (issn:
1520-6106
)
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DOI:
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10.1021/jp304708y
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Publisher:
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American Chemical Society
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Publisher version:
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http://dx.doi.org/10.1021/jp304708y
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Project ID:
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info:eu-repo/grantAgreement/Generalitat Valenciana//GV%2F2009%2F104/ES/Estudio de la Fotoperoxidación de Lípidos de Membrana por Fármacos/
info:eu-repo/grantAgreement/MICINN//AP2008-03295/ES/AP2008-03295/ /
info:eu-repo/grantAgreement/MICINN//CTQ2009-13699/ES/Mecanismos fotoquímicos del daño al ADN y su reparación. Fotosensibilización frente a fotoprotección/ /
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Thanks:
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We gratefully acknowledge financial support from the Generalitat Valenciana (GV/2009/104 and Prometeo Program 2008/090), the Spanish Government (Red RETICS de Investigacion de Reacciones Adversas a Alergenos y Farmacos ...[+]
We gratefully acknowledge financial support from the Generalitat Valenciana (GV/2009/104 and Prometeo Program 2008/090), the Spanish Government (Red RETICS de Investigacion de Reacciones Adversas a Alergenos y Farmacos (RIRAAF)), CTQ2009-13699 and Predoctoral FPU fellowship AP2008-03295 for M. G.-M.).
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Type:
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Artículo
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