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A meta-analysis reveals the commonalities and differences in Arabidopsis thaliana response to different viral pathogens

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A meta-analysis reveals the commonalities and differences in Arabidopsis thaliana response to different viral pathogens

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dc.contributor.author Rodrigo Tarrega, Guillermo es_ES
dc.contributor.author Carrera Montesinos, Javier es_ES
dc.contributor.author Ruiz-Ferrer, Virginia es_ES
dc.contributor.author Del Toro, F.J. es_ES
dc.contributor.author Llave, C es_ES
dc.contributor.author Voinnet, O. es_ES
dc.contributor.author Elena Fito, Santiago Fco es_ES
dc.date.accessioned 2014-07-16T09:33:17Z
dc.date.available 2014-07-16T09:33:17Z
dc.date.issued 2012-07
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10251/38843
dc.description.abstract Understanding the mechanisms by which plants trigger host defenses in response to viruses has been a challenging problem owing to the multiplicity of factors and complexity of interactions involved. The advent of genomic techniques, however, has opened the possibility to grasp a global picture of the interaction. Here, we used Arabidopsis thaliana to identify and compare genes that are differentially regulated upon infection with seven distinct (+)ssRNA and one ssDNA plant viruses. In the first approach, we established lists of genes differentially affected by each virus and compared their involvement in biological functions and metabolic processes. We found that phylogenetically related viruses significantly alter the expression of similar genes and that viruses naturally infecting Brassicaceae display a greater overlap in the plant response. In the second approach, virus-regulated genes were contextualized using models of transcriptional and protein-protein interaction networks of A. thaliana. Our results confirm that host cells undergo significant reprogramming of their transcriptome during infection, which is possibly a central requirement for the mounting of host defenses. We uncovered a general mode of action in which perturbations preferentially affect genes that are highly connected, central and organized in modules. © 2012 Rodrigo et al. es_ES
dc.description.sponsorship This work was supported by the Spanish Ministerio de Ciencia e Innovacion (MICINN) grants BFU2009-06993 (S. F. E.) and BIO2006-13107 (C. L.) and by Generalitat Valenciana grant PROMETEO2010/016 (S. F. E.). G. R. is supported by a graduate fellowship from the Generalitat Valenciana (BFPI2007-160) and J.C. by a contract from MICINN grant TIN2006-12860. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. en_EN
dc.language Inglés es_ES
dc.publisher Public Library of Science es_ES
dc.relation.ispartof PLoS ONE es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Single stranded DNA es_ES
dc.subject Single stranded RNA es_ES
dc.subject Transcriptome es_ES
dc.subject Arabidopsis es_ES
dc.subject Article es_ES
dc.subject Brassicaceae es_ES
dc.subject Gene expression es_ES
dc.subject Gene function es_ES
dc.subject Gene identification es_ES
dc.subject Genetic regulation es_ES
dc.subject Host cell es_ES
dc.subject Host pathogen interaction es_ES
dc.subject Host resistance es_ES
dc.subject Nonhuman es_ES
dc.subject Phylogeny es_ES
dc.subject Plant immunity es_ES
dc.subject Plant virus es_ES
dc.subject Protein protein interaction es_ES
dc.subject Systems biology es_ES
dc.subject Transcriptional regulation es_ES
dc.subject Transcriptomics es_ES
dc.subject Viral plant disease es_ES
dc.title A meta-analysis reveals the commonalities and differences in Arabidopsis thaliana response to different viral pathogens es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1371/journal.pone.0040526
dc.relation.projectID info:eu-repo/grantAgreement/MEC//BIO2006-13107/ES/ANALISIS DE LA FUNCION Y ESTRUCTURA DE MICROARNS Y OTROS PEQUEÑOS ARNS COMO REGULADORES GENICOS DURANTE LAS INFECCIONES VIRALES DE LAS PLANTAS/ / es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO%2F2010%2F016/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MEC//TIN2006-12860/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//BFU2009-06993/ES/Biologia Evolutiva Y De Sistemas De La Emergencia De Fitovirus De Rna/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Instrumentación para Imagen Molecular - Institut d'Instrumentació per a Imatge Molecular es_ES
dc.description.bibliographicCitation Rodrigo Tarrega, G.; Carrera Montesinos, J.; Ruiz-Ferrer, V.; Del Toro, F.; Llave, C.; Voinnet, O.; Elena Fito, SF. (2012). A meta-analysis reveals the commonalities and differences in Arabidopsis thaliana response to different viral pathogens. PLoS ONE. 7(7):40526-40526. https://doi.org/10.1371/journal.pone.0040526 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1371/journal.pone.0040526 es_ES
dc.description.upvformatpinicio 40526 es_ES
dc.description.upvformatpfin 40526 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 7 es_ES
dc.description.issue 7 es_ES
dc.relation.senia 232199
dc.identifier.pmid 22808182 en_EN
dc.identifier.pmcid PMC3395709 en_EN
dc.contributor.funder Ministerio de Educación y Ciencia es_ES
dc.contributor.funder Generalitat Valenciana es_ES
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