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Semisynthesis, Cytotoxic Activity, and Oral Availability of New Lipophilic 9-Substituted Camptothecim Derivatives

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Semisynthesis, Cytotoxic Activity, and Oral Availability of New Lipophilic 9-Substituted Camptothecim Derivatives

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Rodríguez Berna, G.; Díaz Cabañas, MJ.; Mangas Sanjuan, V.; Gonzalez Alvarez, M.; González Álvarez, I.; Abasolo, I.; Simo Schwartz, J.... (2013). Semisynthesis, Cytotoxic Activity, and Oral Availability of New Lipophilic 9-Substituted Camptothecim Derivatives. ACS Medicinal Chemistry Letters. 4(7):651-655. doi:10.1021/ml400125z

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/40666

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Title: Semisynthesis, Cytotoxic Activity, and Oral Availability of New Lipophilic 9-Substituted Camptothecim Derivatives
Author:
UPV Unit: Universitat Politècnica de València. Departamento de Química - Departament de Química
Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química
Issued date:
Abstract:
Despite that 9-substituted camptothecins are promising candidates in cancer therapy, the limited accessibility to this position has reduced the studies of these derivatives to a few standard modifications. We report herein ...[+]
Subjects: Lipophilic camptothecin , Tscherniac−Einhorn derivatives , 9-substituted camptothecins , Oral administration
Copyrigths: Cerrado
Source:
ACS Medicinal Chemistry Letters. (issn: 1948-5875 )
DOI: 10.1021/ml400125z
Publisher:
American Chemical Society
Publisher version: http://dx.doi.org/10.1021/ml400125z
Type: Artículo

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