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2,3,9- and 2,3,11-Trisubstituted tetrahydroprotoberberines as D2 dopaminergic ligands

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2,3,9- and 2,3,11-Trisubstituted tetrahydroprotoberberines as D2 dopaminergic ligands

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Párraga, J.; Cabedo Escrig, N.; Andujar, S.; Piqueras, L.; Moreno, L.; Galán, A.; Angelina, E.... (2013). 2,3,9- and 2,3,11-Trisubstituted tetrahydroprotoberberines as D2 dopaminergic ligands. European Journal of Medicinal Chemistry. 68:150-166. https://doi.org/10.1016/j.ejmech.2013.07.036

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Title: 2,3,9- and 2,3,11-Trisubstituted tetrahydroprotoberberines as D2 dopaminergic ligands
Author: Párraga, Javier Cabedo Escrig, Nuria Andujar, Sebastián Piqueras, Laura Moreno, Laura Galán, Abraham Angelina, Emilio Enriz, Ricardo D. Ivorra, María Dolores Sanz, María Jesús Cortes, Diego
UPV Unit: Universitat Politècnica de València. Centro de Ecología Química Agrícola - Centre d'Ecologia Química Agrícola
Universitat Politècnica de València. Instituto Agroforestal Mediterráneo - Institut Agroforestal Mediterrani
Issued date:
Abstract:
Dopamine-mediated neurotransmission plays an important role in relevant psychiatric and neurological disorders. Nowadays, there is an enormous interest in the development of new dopamine receptors (DR) acting drugs as ...[+]
Subjects: Tetrahydroprotoberberines , Dopamine receptors , Structure-activity relationships cytotoxicity , MTT and cytofluorometric analysis , Theoretical calculations
Copyrigths: Reserva de todos los derechos
Source:
European Journal of Medicinal Chemistry. (issn: 0223-5234 )
DOI: 10.1016/j.ejmech.2013.07.036
Publisher:
Elsevier
Publisher version: http://dx.doi.org/10.1016/j.ejmech.2013.07.036
Project ID:
info:eu-repo/grantAgreement/MICINN//SAF2011-23777/ES/ESTUDIO DE LOS MECANISMOS MOLECULARES Y CELULARES EN LA DISFUNCION ENDOTELIAL ASOCIADA A ENFERMEDADES CON INFLAMACION SISTEMICA QUE PODRIAN INDUCIR DESORDENES CARDIOVASCULARES/
info:eu-repo/grantAgreement/MICINN//RD08%2F0075%2F0016/ES/RED DE INVESTIGACIÓN EN INFLAMACIÓN Y ENFERMEDADES REUMÁTICAS/
Thanks:
This study was supported by grants SAF2011-23777, Spanish Ministry of Economy and Competitiveness, RIER RD08/0075/0016, Carlos III Health Institute, Spanish Ministry of Health and the European Regional Development Fund ...[+]
Type: Artículo

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