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Profound Sedation with Propofol Modifies Atrial Fibrillation Dynamics

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Profound Sedation with Propofol Modifies Atrial Fibrillation Dynamics

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dc.contributor.author Cervigón Abad, Raquel es_ES
dc.contributor.author Moreno, Javier es_ES
dc.contributor.author Pérez Villacastín, Julian es_ES
dc.contributor.author Castells Ramón, Francisco Sales es_ES
dc.date.accessioned 2014-12-17T18:17:26Z
dc.date.available 2014-12-17T18:17:26Z
dc.date.issued 2013-09
dc.identifier.issn 0147-8389
dc.identifier.uri http://hdl.handle.net/10251/45559
dc.description.abstract During atrial fibrillation (AF), multiple wandering propagation wavelets at high rates drift around both atria under controversial hierarchical models. Antiarrhythmic drugs modify the cardiac ionic currents supporting the fibrillation process within the atria, and can alter AF propagation dynamics and even terminate the arrhythmia. However, some other drugs, theoretically nonantiarrhythmic, may slightly block particular cardiac ionic currents through uncertain mechanisms in such a subtle way at regular heart rates that may have been pharmacologically overlooked. These potential effects might be better exposed at much higher activation rates as in AF, where atrial cells depolarize over 400 times per second. In this review, we aimed to compile and discuss results from several studies evaluating the net effect of profound sedation with propofol on atrial cells and atrioventricular (AV) conduction. Propofol is a very commonly used anesthetic agent, and its possible effect on AF dynamics has systematically not been taken into account in the myriad of clinical studies dealing with AF intracardiac recordings. The possible effect of sedation with propofol on AF was evaluated through the analysis of AF propagation patterns before and after its infusion in a series of patients submitted to pulmonary vein ablation. Effect on AV conduction will be discussed as well. es_ES
dc.description.sponsorship This work was supported by the Ministry of Education and Science of Spain (Ref: EASI TEC2009–13939). es_ES
dc.language Inglés es_ES
dc.publisher Wiley: 12 months es_ES
dc.relation.ispartof Pacing and Clinical Electrophysiology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject atrial fibrillation es_ES
dc.subject anesthetic es_ES
dc.subject organization indexes es_ES
dc.subject intra-atrial electrograms es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Profound Sedation with Propofol Modifies Atrial Fibrillation Dynamics es_ES
dc.type Reseña es_ES
dc.identifier.doi 10.1111/pace.12137
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//TEC2009-13939/ES/Desarrollo De Tecnicas Avanzadas De Analisis Y Caracterizacion De Mapas De Propagacion Para La Ayuda Al Diagnostico Electrocardiografico/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.description.bibliographicCitation Cervigón Abad, R.; Moreno, J.; Pérez Villacastín, J.; Castells Ramón, FS. (2013). Profound Sedation with Propofol Modifies Atrial Fibrillation Dynamics. Pacing and Clinical Electrophysiology. 36(9):1176-1188. https://doi.org/10.1111/pace.12137 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1111/pace.12137 es_ES
dc.description.upvformatpinicio 1176 es_ES
dc.description.upvformatpfin 1188 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 36 es_ES
dc.description.issue 9 es_ES
dc.relation.senia 252583
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
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