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ALBIRA: A small animal PET/SPECT/CT imaging system

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ALBIRA: A small animal PET/SPECT/CT imaging system

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dc.contributor.author Sánchez Martínez, Filomeno es_ES
dc.contributor.author Orero Palomares, Abel es_ES
dc.contributor.author Soriano Asensi, Antonio es_ES
dc.contributor.author Correcher Salvador, Carlos es_ES
dc.contributor.author Conde Castellanos, Pablo Eloy es_ES
dc.contributor.author González Martínez, Antonio Javier es_ES
dc.contributor.author Hernández Hernández, Liczandro es_ES
dc.contributor.author Moliner Martínez, Laura es_ES
dc.contributor.author Rodríguez Álvarez, María José es_ES
dc.contributor.author Vidal San Sebastián, Luis Fernando es_ES
dc.contributor.author Benlloch Baviera, Jose María es_ES
dc.contributor.author Chapman, S.E. es_ES
dc.contributor.author Leevy, W.M.
dc.date.accessioned 2015-01-19T14:56:46Z
dc.date.issued 2013-05
dc.identifier.issn 0094-2405
dc.identifier.uri http://hdl.handle.net/10251/46182
dc.description.abstract Purpose: The authors have developed a trimodal PET/SPECT/CT scanner for small animal imaging. The gamma ray subsystems are based on monolithic crystals coupled to multianode photomultiplier tubes (MA-PMTs), while computed tomography (CT) comprises a commercially available microfocus x-ray tube and a CsI scintillator 2D pixelated flat panel x-ray detector. In this study the authors will report on the design and performance evaluation of the multimodal system. Methods: X-ray transmission measurements are performed based on cone-beam geometry. Individual projections were acquired by rotating the x-ray tube and the 2D flat panel detector, thus making possible a transaxial field of view (FOV) of roughly 80 mm in diameter and an axial FOV of 65 mm for the CT system. The single photon emission computed tomography (SPECT) component has a dual head detector geometry mounted on a rotating gantry. The distance between the SPECT module detectors can be varied in order to optimize specific user requirements, including variable FOV. The positron emission tomography (PET) system is made up of eight compact modules forming an octagon with an axial FOV of 40 mm and a transaxial FOV of 80 mm in diameter. The main CT image quality parameters (spatial resolution and uniformity) have been determined. In the case of the SPECT, the tomographic spatial resolution and system sensitivity have been evaluated with a99mTc solution using single-pinhole and multi-pinhole collimators. PET and SPECT images were reconstructed using three-dimensional (3D) maximum likelihood and ordered subset expectation maximization (MLEM and OSEM) algorithms developed by the authors, whereas the CT images were obtained using a 3D based FBP algorithm. Results: CT spatial resolution was 85μm while a uniformity of 2.7% was obtained for a water filled phantom at 45 kV. The SPECT spatial resolution was better than 0.8 mm measured with a Derenzo-like phantom for a FOV of 20 mm using a 1-mm pinhole aperture collimator. The full width at half-maximum PET radial spatial resolution at the center of the field of view was 1.55 mm. The SPECT system sensitivity for a FOV of 20 mm and 15% energy window was 700 cps/MBq (7.8 × 10−2%) using a multi-pinhole equipped with five apertures 1 mm in diameter, whereas the PET absolute sensitivity was 2% for a 350–650 keV energy window and a 5 ns timing window. Several animal images are also presented. Conclusions: The new small animal PET/SPECT/CT proposed here exhibits high performance, producing high-quality images suitable for studies with small animals. Monolithic design for PET and SPECT scintillator crystals reduces cost and complexity without significant performance degradation. es_ES
dc.description.sponsorship This study was supported by the Spanish Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica (I+D+I) under Grant No. FIS2010-21216-CO2-01 and Valencian Local Government under Grant PROMETEO 2008/114. The authors also thank Brennan Holt for checking and correcting the text. en_EN
dc.language Inglés es_ES
dc.publisher American Association of Physicists in Medicine: Medical Physics es_ES
dc.relation.ispartof Medical Physics es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Nuclear medicine es_ES
dc.subject Radionuclide imaging es_ES
dc.subject Small animal imaging es_ES
dc.subject Integrated PET/SPECT/CT scanner es_ES
dc.subject.classification MATEMATICA APLICADA es_ES
dc.title ALBIRA: A small animal PET/SPECT/CT imaging system es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1118/1.4800798
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//FIS2010-21216-C02-01/ES/DESARROLLO DEL DETECTOR PET%2FRM PARA DIAGNOSTICO DE ENFERMEDADES NEURODEGENERATIVAS./ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO08%2F2008%2F114/ES/Desarrollo de tecnología PET%2FRM para estudio cerebro en humanos/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Instrumentación para Imagen Molecular - Institut d'Instrumentació per a Imatge Molecular es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada es_ES
dc.description.bibliographicCitation Sánchez Martínez, F.; Orero Palomares, A.; Soriano Asensi, A.; Correcher Salvador, C.; Conde Castellanos, PE.; González Martínez, AJ.; Hernández Hernández, L.... (2013). ALBIRA: A small animal PET/SPECT/CT imaging system. Medical Physics. 40(5):5190601-5190611. https://doi.org/10.1118/1.4800798 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1118/1.4800798 es_ES
dc.description.upvformatpinicio 5190601 es_ES
dc.description.upvformatpfin 5190611 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 40 es_ES
dc.description.issue 5 es_ES
dc.relation.senia 246109
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Generalitat Valenciana es_ES


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