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Computer modeling and ex vivo experiments with a (saline-linked) irrigated electrode for RF-assisted heating.

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Computer modeling and ex vivo experiments with a (saline-linked) irrigated electrode for RF-assisted heating.

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dc.contributor.author Arenas Puig, Francisco Javier es_ES
dc.contributor.author Pérez Martínez, Juan José es_ES
dc.contributor.author Trujillo Guillen, Macarena es_ES
dc.contributor.author Berjano Zanón, Enrique es_ES
dc.date.accessioned 2015-03-09T10:27:32Z
dc.date.available 2015-03-09T10:27:32Z
dc.date.issued 2014-12-12
dc.identifier.issn 1475-925X
dc.identifier.uri http://hdl.handle.net/10251/47869
dc.description.abstract Background Externally irrigated radiofrequency (RF) electrodes have been widely used to thermally ablate tumors in surface tissue and to thermally coagulate the transection plane during a surgical resection. As far as we know, no mathematical model has yet been developed to study the electrical and thermal performance of these electrodes, especially the role of the saline layer that forms around the electrode. Methods Numerical models of a TissueLink device model DS3.0 (Salient Surgical Technologies, Portsmouth, NH, USA) were developed. Irrigation was modeled including a saline layer and a heat convection term in the governing equation. Ex vivo experiments based on fragments of bovine hepatic tissue were conducted to obtain information which was used in building the numerical model. We compared the 60°C isotherm of the computer results with the whitening contour in the heated samples. Results Computer and experimental results were in fine agreement in terms of lesion depth (2.4 mm in the simulations and 2.4 ± 0.6 mm in the experiments). In contrast, the lesion width was greater in the simulation (9.6 mm vs. 7.8 ± 1.8 mm). The computer simulations allowed us to explain the role of the saline layer in creating the thermal lesion. Impedance gradually decreased as heating proceeded. The saline was not observed to boil. In the proximity of the electrode (around 1 mm) the thermal lesion was mainly created by the RF power in this zone, while at a further distance the thermal lesion was created by the hot saline on the tissue surface by simple thermal conduction. Including the heat convection term associated with the saline velocity in the governing equation was crucial to verifying that the saline layer had not reached boiling temperature. Conclusions The model reproduced thermal performance during heating in terms of lesion depth, and provided an explanation for: 1) the relationship between impedance, electrode insertion depth, and saline layer, and 2) the process of creating thermal lesions in the tissue with this type of electrode. es_ES
dc.description.sponsorship This work received financial support from the Spanish "Plan Nacional de I + D + I del Ministerio de Ciencia e Innovacion" (Grant No. TEC2011-27133-C02-01). en_EN
dc.language Inglés es_ES
dc.publisher BioMed Central es_ES
dc.relation Spanish “Plan Nacional de I + D + I del Ministerio de Ciencia e Innovación” (Grant No. TEC2011-27133-C02-01) es_ES
dc.relation.ispartof BioMedical Engineering OnLine es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Computer modeling es_ES
dc.subject Irrigated electrode es_ES
dc.subject Mathematical modeling es_ES
dc.subject Radiofrequency ablation es_ES
dc.subject Radiofrequency-assisted resection es_ES
dc.subject Saline-linked technology es_ES
dc.subject.classification MATEMATICA APLICADA es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Computer modeling and ex vivo experiments with a (saline-linked) irrigated electrode for RF-assisted heating. es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1186/1475-925X-13-164
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada es_ES
dc.description.bibliographicCitation Arenas Puig, FJ.; Pérez Martínez, JJ.; Trujillo Guillen, M.; Berjano Zanón, E. (2014). Computer modeling and ex vivo experiments with a (saline-linked) irrigated electrode for RF-assisted heating. BioMedical Engineering OnLine. 13(1):1-16. doi:10.1186/1475-925X-13-164 es_ES
dc.description.accrualMethod Senia es_ES
dc.relation.publisherversion http://dx.doi.org/10.1186/1475-925X-13-164 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 16 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 13 es_ES
dc.description.issue 1 es_ES
dc.relation.senia 277676
dc.identifier.pmid 25494912 en_EN
dc.identifier.pmcid PMC4271499 en_EN


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