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Endocrine disruption in thicklip grey mullet (Chelon labrosus) from the Urdaibai Biosphere Reserve (Bay of Biscay, Southwestern Europe)

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Endocrine disruption in thicklip grey mullet (Chelon labrosus) from the Urdaibai Biosphere Reserve (Bay of Biscay, Southwestern Europe)

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dc.contributor.author Puy-Azurmendi, Eunate es_ES
dc.contributor.author Ortiz-Zarragoitia, Maren es_ES
dc.contributor.author Villagrasa, Marta es_ES
dc.contributor.author Kuster, Marina es_ES
dc.contributor.author Aragón Revuelta, Pilar es_ES
dc.contributor.author Atienza Boronat, Mª Julia es_ES
dc.contributor.author Puchades Pla, Rosa es_ES
dc.contributor.author Maquieira Catala, Ángel es_ES
dc.contributor.author Domínguez, Carmen es_ES
dc.contributor.author López de Alda, Miren es_ES
dc.contributor.author Fernandes, Denise es_ES
dc.contributor.author Porte, Cinta es_ES
dc.contributor.author Bayona, Josep Maria es_ES
dc.contributor.author Barceló, Damiá es_ES
dc.contributor.author Cajaraville, Miren P. es_ES
dc.date.accessioned 2015-03-25T19:28:22Z
dc.date.available 2015-03-25T19:28:22Z
dc.date.issued 2013-01
dc.identifier.issn 0048-9697
dc.identifier.uri http://hdl.handle.net/10251/48310
dc.description.abstract Endocrine disruptors (EDs) interfere with the development and functioning of the endocrine system, causing reproductive disturbance in aquatic wildlife. The aim of the present work was to determine the presence of EDs in sediments and to investigate possible exposure and effects of EDs in the estuary of the Urdaibai Biosphere Reserve (Gernika) in comparison with the Arriluze marina. For this, gonad histology, plasma vitellogenin (VTG) protein levels and mRNA levels of vitellogenin (vtg), cyp19 aromatases, estrogen receptor (er) and retinoid X receptor (rxr) were studied in Chelon labrosus. The presence of alkylphenols (APs) in fish bile was also assessed. In sediments, estrogenic hormones were below the detection limit and levels of bisphenol A were very low. In Gernika organotin compounds were low but in Arriluze levels of up to 12 μg/g were found. Moderate levels of APs and phthalate levels of up to 8 μg/g were found in sediments. In fish, a high prevalence up to 33% of intersex gonads was found in Gernika, whereas only one intersex was found in Arriluze. Accordingly, mullets from Gernika showed higher concentrations of APs in bile. VTG protein levels were detected not only in females but also in some undifferentiated, male and intersex fish. mRNA of vtg was detected in one male from Gernika. mRNA of er and rxr showed significant differences between seasons. In conclusion, the present study demonstrated that C. labrosus from the Urdaibai estuary were exposed to EDs and showed clear signs of endocrine disruption. es_ES
dc.description.sponsorship This work was supported by Catedra UNESCO of the University of the Basque Country (UPV/EHU) through the project DERBiUr (UNESCO06/19), by the University of the Basque Country through a grant to the Unit of Formation and Research (UFI 11/37), by the Basque Government through the project ETORTEK-IMPRES and a grant to consolidated research groups (GIC07/26-IT-393-07), and by MICINN through the projects CEMAGUA (CGL2007-64551/HID) and SCARCE (Consolider-Ingenio 2010 CSD2009-00065). Denise Fernandes acknowledges a postdoctoral fellowship (SFRH/BPD/34289/2006) from the Portuguese Fundacao para a Ciencia e Tecnologia (FCT) of the Ministry of Science and Technology of Portugal. The help of Drs. T. Serrano and M.C. Barbero with the examination of gonad preparations is greatly acknowledged. en_EN
dc.language Español es_ES
dc.publisher Elsevier es_ES
dc.relation Catedra UNESCO of the University of the Basque Country (UPV/EHU) [UNESCO06/19]; University of the Basque Country [UFI 11/37]; Basque Government [GIC07/26-IT-393-07]; MICINN through the project CEMAGUA [CGL2007-64551/HID]; MICINN through the project SCARCE [CSD2009-00065]; Portuguese Fundacao para a Ciencia e Tecnologia (FCT) of the Ministry of Science and Technology of Portugal [SFRH/BPD/34289/2006] es_ES
dc.relation.ispartof Science of the Total Environment es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Endocrine disruptors in sediments and fish bile es_ES
dc.subject Intersex gonad es_ES
dc.subject Vitellogenin es_ES
dc.subject Expression of aromatase and nuclear receptors es_ES
dc.subject Urdaibai Biosphere Reserve es_ES
dc.subject Thicklip grey mullet Chelon labrosus es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.title Endocrine disruption in thicklip grey mullet (Chelon labrosus) from the Urdaibai Biosphere Reserve (Bay of Biscay, Southwestern Europe) es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.scitotenv.2012.10.078
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Puy-Azurmendi, E.; Ortiz-Zarragoitia, M.; Villagrasa, M.; Kuster, M.; Aragón Revuelta, P.; Atienza Boronat, MJ.; Puchades Pla, R.... (2013). Endocrine disruption in thicklip grey mullet (Chelon labrosus) from the Urdaibai Biosphere Reserve (Bay of Biscay, Southwestern Europe). Science of the Total Environment. 443:233-244. doi:10.1016/j.scitotenv.2012.10.078 es_ES
dc.description.accrualMethod Senia es_ES
dc.relation.publisherversion http://dx.doi.org/10.1016/j.scitotenv.2012.10.078 es_ES
dc.description.upvformatpinicio 233 es_ES
dc.description.upvformatpfin 244 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 443 es_ES
dc.relation.senia 232765


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