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Modelling and simulation of antibody purification

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Modelling and simulation of antibody purification

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dc.contributor.advisor Nilson, Bernt es_ES
dc.contributor.author Pérez Serrano, Ferran es_ES
dc.date.accessioned 2015-04-09T10:22:06Z
dc.date.available 2015-04-09T10:22:06Z
dc.date.created 2015-03
dc.date.issued 2015-04-09
dc.identifier.uri http://hdl.handle.net/10251/48721
dc.description.abstract Consulta en la Biblioteca ETSI Industriales (Riunet) es_ES
dc.description.abstract [EN] Due to their high specificity against target antigens, monoclonal antibodies (mAbs) have proven to be a very powerful tool for diagnostic and therapeutic purpose against several diseases. Currently there are over 26 mAb approved for therapeutic use by the FDA. The manufacture of mAbs is a complex process where purification plays a key role. This project proposes and simulates a purification process based on an array of chromatographic columns. The different employed columns were modelled by kinetic dispersive models using parameters from available bibliography as well as some assumptions. The proposed method consists of five columns connected in series and offered arguably good results with a purity and yield of the target mAb of~90% and ~85% respectively es_ES
dc.language Inglés es_ES
dc.publisher Universitat Politècnica de València es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Consulta en la Biblioteca ETSI Industriales es_ES
dc.subject Purificación de anticuerpos es_ES
dc.subject Biomedicina es_ES
dc.subject.classification INGENIERIA QUIMICA es_ES
dc.subject.other Ingeniero Químico-Enginyer Químic es_ES
dc.title Modelling and simulation of antibody purification es_ES
dc.type Proyecto/Trabajo fin de carrera/grado es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials es_ES
dc.description.bibliographicCitation Pérez Serrano, F. (2015). Modelling and simulation of antibody purification. http://hdl.handle.net/10251/48721. es_ES
dc.description.accrualMethod Archivo delegado es_ES


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