- -

Small animal PET scanner based on monolithic LYSO crystals: Performance evaluation

RiuNet: Institutional repository of the Polithecnic University of Valencia

Share/Send to

Cited by

Statistics

Small animal PET scanner based on monolithic LYSO crystals: Performance evaluation

Show simple item record

Files in this item

dc.contributor.author Sánchez Martínez, Filomeno es_ES
dc.contributor.author Moliner Martínez, Laura es_ES
dc.contributor.author Correcher, C. es_ES
dc.contributor.author González Martínez, Antonio Javier es_ES
dc.contributor.author Orero Palomares, Abel es_ES
dc.contributor.author Carles Fariña, Montserrat es_ES
dc.contributor.author Soriano Asensi, Antonio es_ES
dc.contributor.author Rodríguez Álvarez, María José es_ES
dc.contributor.author Medina, L.A es_ES
dc.contributor.author Mora Mas, Francisco José es_ES
dc.contributor.author Benlloch Baviera, Jose María es_ES
dc.date.accessioned 2015-04-23T15:59:48Z
dc.date.issued 2012
dc.identifier.issn 0094-2405
dc.identifier.uri http://hdl.handle.net/10251/49202
dc.description.abstract Purpose: The authors have developed a small animal Positron emission tomography(PET)scanner based on monolithic LYSO crystals coupled to multi-anode photomultiplier tubes (MA-PMTs). In this study, the authors report on the design, calibration procedure, and performance evaluation of a PET system that the authors have developed using this innovative nonpixelated detector design. Methods : The scanner is made up of eight compact modules forming an octagon with an axial field of view (FOV) of 40 mm and a transaxial FOV of 80 mm diameter. In order to fully determine its performance, a recently issued National Electrical Manufacturers Association (NEMA) NU-4 protocol, specifically developed for small animal PETscanners, has been followed. By measuring the width of light distribution collected in the MA-PMT the authors are able to determine depth of interaction (DOI), thus making the proper identification of lines of response (LORs) with large incidence angles possible. PET performances are compared with those obtained with currently commercially available small animal PETscanners. Results : At axial center when the point-like source is located at 5 mm from the radial center, the spatial resolution measured was 1.65, 1.80, and 1.86 mm full width at half maximum (FWHM) for radial, tangential, and axial image profiles, respectively. A system scatter fraction of 7.5% (mouse-like phantom) and 13% (rat-like phantom) was obtained, while the maximum noise equivalent count rate (NECR) was 16.9 kcps at 12.7 MBq (0.37 MBq/ml) for mouse-like phantom and 12.8 kcps at 12.4 MBq (0.042 MBq/ml) for rat-like phantom The peak absolute sensitivity in the center of the FOV is 2% for a 30% peak energy window. Several animal images are also presented. Conclusions: The overall performance of our small animal PET is comparable to that obtained with much more complex crystal pixelated PET systems. Moreover, the new proposed PET produces high-quality images suitable for studies with small animals. es_ES
dc.description.sponsorship This work was supported by the Spanish Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica (I+D+I) under Grant No. FIS2010-21216-CO2-01 and Valencian Local Government under Grant No. PROMETEO 2008/114. The authors would like to thank Andrew Duncan for checking and correcting the text. en_EN
dc.language Inglés es_ES
dc.publisher American Association of Physicists in Medicine: Medical Physics es_ES
dc.relation.ispartof Medical Physics es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Nuclear medicine es_ES
dc.subject Radionuclide imaging es_ES
dc.subject Small animal imaging es_ES
dc.subject PET scanner es_ES
dc.subject.classification MATEMATICA APLICADA es_ES
dc.subject.classification ORGANIZACION DE EMPRESAS es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Small animal PET scanner based on monolithic LYSO crystals: Performance evaluation es_ES
dc.type Artículo es_ES
dc.embargo.lift 10000-01-01
dc.embargo.terms forever es_ES
dc.identifier.doi 10.1118/1.3673771
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//FIS2010-21216-C02-01/ES/DESARROLLO DEL DETECTOR PET%2FRM PARA DIAGNOSTICO DE ENFERMEDADES NEURODEGENERATIVAS./ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO08%2F2008%2F114/ES/Desarrollo de tecnología PET%2FRM para estudio cerebro en humanos/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Instrumentación para Imagen Molecular - Institut d'Instrumentació per a Imatge Molecular es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.description.bibliographicCitation Sánchez Martínez, F.; Moliner Martínez, L.; Correcher, C.; González Martínez, AJ.; Orero Palomares, A.; Carles Fariña, M.; Soriano Asensi, A.... (2012). Small animal PET scanner based on monolithic LYSO crystals: Performance evaluation. Medical Physics. 39(4):643-653. https://doi.org/10.1118/1.3673771 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1118/1.3673771 es_ES
dc.description.upvformatpinicio 643 es_ES
dc.description.upvformatpfin 653 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 39 es_ES
dc.description.issue 4 es_ES
dc.relation.senia 212933
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.description.references Myers, R. (2001). The biological application of small animal PET imaging. Nuclear Medicine and Biology, 28(5), 585-593. doi:10.1016/s0969-8051(01)00213-x es_ES
dc.description.references Chatziioannou, A. F. (2002). Molecular imaging of small animals with dedicated PET tomographs. European Journal of Nuclear Medicine and Molecular Imaging, 29(1), 98-114. doi:10.1007/s00259-001-0683-3 es_ES
dc.description.references Cherry, S. R. (2001). Fundamentals of Positron Emission Tomography and Applications in Preclinical Drug Development. The Journal of Clinical Pharmacology, 41(5), 482-491. doi:10.1177/00912700122010357 es_ES
dc.description.references Myers, R. (2002). Small animal PET. European Neuropsychopharmacology, 12(6), 545-555. doi:10.1016/s0924-977x(02)00103-7 es_ES
dc.description.references Hume, S., & Myers, R. (2002). Dedicated Small Animal Scanners: A New Tool for Drug Development? Current Pharmaceutical Design, 8(16), 1497-1511. doi:10.2174/1381612023394412 es_ES
dc.description.references Gu, Y., Matteson, J. L., Skelton, R. T., Deal, A. C., Stephan, E. A., Duttweiler, F., … Levin, C. S. (2011). Study of a high-resolution, 3D positioning cadmium zinc telluride detector for PET. Physics in Medicine and Biology, 56(6), 1563-1584. doi:10.1088/0031-9155/56/6/004 es_ES
dc.description.references Lage, E., Vaquero, J. J., Sisniega, A., España, S., Tapias, G., Abella, M., … Desco, M. (2009). Design and performance evaluation of a coplanar multimodality scanner for rodent imaging. Physics in Medicine and Biology, 54(18), 5427-5441. doi:10.1088/0031-9155/54/18/005 es_ES
dc.description.references S. A. Kis I. Lajtos M. Emri L. Tron G. Opposits T. Bükki Gy. Hegyesi J. Imrek I. Valastyán J. Molnár D. Novák L. Balkay Performance test of the MiniPET-II small animal scanner according to the NEMA NU-4 standard IEEE Nuclear Science Symposium Conference Record 3185 3189 2009 es_ES
dc.description.references Bao, Q., Newport, D., Chen, M., Stout, D. B., & Chatziioannou, A. F. (2009). Performance Evaluation of the Inveon Dedicated PET Preclinical Tomograph Based on the NEMA NU-4 Standards. Journal of Nuclear Medicine, 50(3), 401-408. doi:10.2967/jnumed.108.056374 es_ES
dc.description.references Prasad, R., Ratib, O., & Zaidi, H. (2010). Performance Evaluation of the FLEX Triumph X-PET Scanner Using the National Electrical Manufacturers Association NU-4 Standards. Journal of Nuclear Medicine, 51(10), 1608-1615. doi:10.2967/jnumed.110.076125 es_ES
dc.description.references Huisman, M. C., Reder, S., Weber, A. W., Ziegler, S. I., & Schwaiger, M. (2006). Performance evaluation of the Philips MOSAIC small animal PET scanner. European Journal of Nuclear Medicine and Molecular Imaging, 34(4), 532-540. doi:10.1007/s00259-006-0271-7 es_ES
dc.description.references Belcari, N., Guerra, A. D., Bartoli, A., Bianchi, D., Lazzarotti, M., Sensi, L., … Sgadò, P. (2007). Evaluation of the performance of the YAP-(S)PET scanner and its application in neuroscience. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 571(1-2), 18-21. doi:10.1016/j.nima.2006.10.021 es_ES
dc.description.references Zhang, H., Bao, Q., Vu, N. T., Silverman, R. W., Taschereau, R., Berry-Pusey, B. N., … Chatziioannou, A. F. (2010). Performance Evaluation of PETbox: A Low Cost Bench Top Preclinical PET Scanner. Molecular Imaging and Biology, 13(5), 949-961. doi:10.1007/s11307-010-0413-y es_ES
dc.description.references Kim, J. S., Lee, J. S., Im, K. C., Kim, S. J., Kim, S.-Y., Lee, D. S., & Moon, D. H. (2007). Performance Measurement of the microPET Focus 120 Scanner. Journal of Nuclear Medicine, 48(9), 1527-1535. doi:10.2967/jnumed.107.040550 es_ES
dc.description.references Canadas, M., Embid, M., Lage, E., Desco, M., Vaquero, J. J., & Perez, J. M. (2011). NEMA NU 4-2008 Performance Measurements of Two Commercial Small-Animal PET Scanners: ClearPET and rPET-1. IEEE Transactions on Nuclear Science, 58(1), 58-65. doi:10.1109/tns.2010.2072935 es_ES
dc.description.references Prasad, R., Ratib, O., & Zaidi, H. (2011). NEMA NU-04-based performance characteristics of the LabPET-8™ small animal PET scanner. Physics in Medicine and Biology, 56(20), 6649-6664. doi:10.1088/0031-9155/56/20/009 es_ES
dc.description.references Benlloch, J. M., Carrilero, V., González, A. J., Catret, J., Lerche, C. W., Abellán, D., … Sebastiá, A. (2007). Scanner calibration of a small animal PET camera based on continuous LSO crystals and flat panel PSPMTs. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 571(1-2), 26-29. doi:10.1016/j.nima.2006.10.020 es_ES
dc.description.references Smith, R. J., Karp, J. S., & Muehllehner, G. (1994). The countrate performance of the volume imaging PENN-PET scanner. IEEE Transactions on Medical Imaging, 13(4), 610-618. doi:10.1109/42.363107 es_ES
dc.description.references Sánchez, F., Benlloch, J. M., Escat, B., Pavón, N., Porras, E., Kadi-Hanifi, D., … Sebastià, A. (2004). Design and tests of a portable mini gamma camera. Medical Physics, 31(6), 1384-1397. doi:10.1118/1.1755570 es_ES
dc.description.references Ling, T., Lewellen, T. K., & Miyaoka, R. S. (2007). Depth of interaction decoding of a continuous crystal detector module. Physics in Medicine and Biology, 52(8), 2213-2228. doi:10.1088/0031-9155/52/8/012 es_ES
dc.description.references Vaska, P., Krishnamoorthy, S., Stoll, S., Woody, C. L., O’Connor, P., Purschke, M., … Villanueva, A. (s. f.). An improved anger detector approach for PET with high resolution and sensitivity. IEEE Symposium Conference Record Nuclear Science 2004. doi:10.1109/nssmic.2004.1466632 es_ES
dc.description.references Antich, P., Malakhov, N., Parkey, R., Slavin, N., & Tsyganov, E. (2002). 3D position readout from thick scintillators. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 480(2-3), 782-787. doi:10.1016/s0168-9002(01)01214-1 es_ES
dc.description.references Lerche, C. W., Döring, M., Ros, A., Herrero, V., Gadea, R., Aliaga, R. J., … Benlloch, J. M. (2009). Depth of interaction detection for -ray imaging. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 600(3), 624-634. doi:10.1016/j.nima.2008.11.151 es_ES
dc.description.references Lerche, C. W., Ros, A., Herrero, V., Esteve, R., Monzo, J. M., Sebastia, A., … Benlloch, J. M. (2008). Dependency of Energy-, Position- and Depth of Interaction Resolution on Scintillation Crystal Coating and Geometry. IEEE Transactions on Nuclear Science, 55(3), 1344-1351. doi:10.1109/tns.2008.920254 es_ES
dc.description.references Siegel, S., Silverman, R. W., Yiping Shao, & Cherry, S. R. (1996). Simple charge division readouts for imaging scintillator arrays using a multi-channel PMT. IEEE Transactions on Nuclear Science, 43(3), 1634-1641. doi:10.1109/23.507162 es_ES
dc.description.references Performance measurements for small animal positron emission tomographs (PETs) 2008 es_ES
dc.description.references Cherry, S. R., & Gambhir, S. S. (2001). Use of Positron Emission Tomography in Animal Research. ILAR Journal, 42(3), 219-232. doi:10.1093/ilar.42.3.219 es_ES


This item appears in the following Collection(s)

Show simple item record