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Mathematical methodology to obtain and compare different embryo scores

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Mathematical methodology to obtain and compare different embryo scores

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dc.contributor.author Debón Aucejo, Ana María es_ES
dc.contributor.author Molina Botella, María Inmaculada es_ES
dc.contributor.author Cabrera García, Suitberto es_ES
dc.contributor.author Pellicer, A. es_ES
dc.date.accessioned 2015-05-06T06:00:31Z
dc.date.available 2015-05-06T06:00:31Z
dc.date.issued 2013
dc.identifier.issn 0895-7177
dc.identifier.uri http://hdl.handle.net/10251/49738
dc.description.abstract In Vitro Fertilization (IVF) units need to decrease multiple pregnancies without affecting their overall success rate. In this study we propose a mathematical model to evaluate an embryo’s potential ability to implant in the uterus. Embryos are graded by the embryologist based on the number of blastomeres, evenness of growth and degree of fragmentation. Therefore, the following variables were considered: number of blastomeres produced by division of the egg after fertilisation (blastomeres), symmetry and fragmentation of the embryo (grade). This model evaluates the embryos assigning them a score which represents their quality. The main result derived from this model is the estimation of the significant improvement in the implantation rate due to the increase in blastomere values and the decrease in grade factor values. But the increase from two–three to four produces more improvement in the implantation rate than two–three to five–six blastomeres. First, statistical models were used to study embryo traceability from transfer to implantation and to evaluate the effect of the quality of the embryos (embryo score) and women’s age on implantation potential. This score was obtained by making predictions from the fitted model which was used to rank embryos in terms of implantation potential. Then we totalled the scores of embryos that had been transferred to each woman for obtaining the Embryo Quality Index (EQI). In addition, we studied the effects of EQI and women’s age on pregnancy. Finally, statistical techniques such as Receiver Operating Characteristics (ROC) and bootstrap procedures were used to assess the accuracy of this model. This embryo score is a quick, efficient and accurate tool to optimise embryo selection for transfers on the second day after fertilisation. This tool is especially useful for transfers involving non-top embryos. es_ES
dc.description.sponsorship This work was partially supported by a grant from the Generalitat Valenciana (grant no. GVPRE/2008/103). The research of AD and SC was partially supported by a grant from Ministerio de Asuntos Exteriores (grant no. A/023444/09) too. The authors are indebted to the anonymous referee whose comments and suggestions improved the paper considerably. en_EN
dc.language Español es_ES
dc.publisher Elsevier es_ES
dc.relation Ministerio de Asuntos Exteriores (grant no. A/023444/09) es_ES
dc.relation Generalitat Valenciana (grant no. GVPRE/2008/103) es_ES
dc.relation.ispartof Mathematical and Computer Modelling es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Bootstrapping es_ES
dc.subject Embryo score es_ES
dc.subject ROC curve es_ES
dc.subject Generalised linear mixed models es_ES
dc.subject Categorical predictors es_ES
dc.subject Generalised linear models es_ES
dc.subject.classification ESTADISTICA E INVESTIGACION OPERATIVA es_ES
dc.subject.classification PRODUCCION ANIMAL es_ES
dc.title Mathematical methodology to obtain and compare different embryo scores es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.mcm.2012.11.027
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Grupo de Fenómenos Ondulatorios (GFO) es_ES
dc.contributor.affiliation Universitat Politècnica de València. Centro de Gestión de la Calidad y del Cambio - Centre de Gestió de la Qualitat i del Canvi es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Estadística e Investigación Operativa Aplicadas y Calidad - Departament d'Estadística i Investigació Operativa Aplicades i Qualitat es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ciencia Animal - Departament de Ciència Animal es_ES
dc.description.bibliographicCitation Debón Aucejo, AM.; Molina Botella, MI.; Cabrera García, S.; Pellicer, A. (2013). Mathematical methodology to obtain and compare different embryo scores. Mathematical and Computer Modelling. 57(5-6):1380-1394. doi:10.1016/j.mcm.2012.11.027 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://www.sciencedirect.com/science/article/pii/S0895717712003408 es_ES
dc.description.upvformatpinicio 1380 es_ES
dc.description.upvformatpfin 1394 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 57 es_ES
dc.description.issue 5-6 es_ES
dc.relation.senia 233643


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