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Gender and functional CYP2C and NAT2 polymorphisms determine the metabolic profile of metamizole

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Gender and functional CYP2C and NAT2 polymorphisms determine the metabolic profile of metamizole

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Martínez, C.; Andreu Ros, MI.; Amo, G.; Miranda Alonso, MÁ.; Esguevillas, G.; Torres, MJ.; Blanca López, N.... (2014). Gender and functional CYP2C and NAT2 polymorphisms determine the metabolic profile of metamizole. Biochemical Pharmacology. 92(3):457-466. doi:10.1016/j.bcp.2014.09.005

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Title: Gender and functional CYP2C and NAT2 polymorphisms determine the metabolic profile of metamizole
Author:
UPV Unit: Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química
Universitat Politècnica de València. Departamento de Química - Departament de Química
Issued date:
Abstract:
Metamizole is a pain-killer drug that has been banned in some countries because of its toxicity, but it is still used in many countries due to its effective analgesic and antispasmodic properties. Although large variability ...[+]
Subjects: Metamizole , Metabolism , Polymorphisms , Biomarkers
Copyrigths: Reserva de todos los derechos
Source:
Biochemical Pharmacology. (issn: 0006-2952 )
DOI: 10.1016/j.bcp.2014.09.005
Publisher:
Elsevier
Publisher version: http://dx.doi.org/10.1016/j.bcp.2014.09.005
Thanks:
We are grateful to Prof. James McCue for assistance in language editing. Financed by grants PS09/00943, PS09/00469, PI12/00241, PI12/00324 and RETICS RD07/0064/0016 and RD12/0013/0002 and RD12/0013/0009 from Fondo de ...[+]
Type: Artículo

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